Polly Fordyce is an Associate Professor of Genetics and Bioengineering and fellow of the ChEM-H Institute at Stanford University.[1] Her laboratory's research focuses on developing and applying new microfluidic platforms for quantitative, high-throughput biophysics and biochemistry and single-cell genomics.
Polly Fordyce | |
|---|---|
| Born | Washington, DC, USA |
| Alma mater | University of Colorado Boulder, BS Stanford University, PhD |
| Known for | High-throughput enzymology, biophysics, microfludiics |
| Awards | Eli Lilly Award in Biological Chemistry National Science Foundation CAREER Award |
| Scientific career | |
| Fields | Bioengineering |
| Institutions | Stanford University |
| Doctoral advisor | Steven Block |
| Other academic advisors | Joseph DeRisi |
| Website | www |
Fordyce was born and raised in Washington, DC.[2]
Education edit
Fordyce double-majored in physics and biology at the University of Colorado Boulder, graduating in 2000. She then began a PhD in the lab of Steven Block at Stanford University, where she worked as part of a team that developed new microscopes for applying force to molecules and understanding how it affected their movements.[3] After receiving her PhD in 2007, she moved to UCSF to pursue postdoctoral research in Joseph DeRisi's laboratory developing high-throughput methods for the analysis of transcription factor interactions.[4] She has been a professor at Stanford since 2014.[2]
Research edit
Fordyce's lab develops approaches for high throughput quantitative biochemistry, biophysics, and single cell assays, using a variety of approaches including microfluidics.[5] One of her lab's accomplishments is the development of the method HT-MEK (High-Throughput Microfluidic Enzyme Kinetics),[6] which enables researchers to analyze the effects of thousands of mutations on an enzyme's activity in a single experiment.[7]
Awards edit
- Graduate Research Fellow, National Science Foundation (2002–2005)
- G. J. Lieberman Fellow, Stanford University (2003–2004)
- Helen Hay Whitney Postdoctoral Fellowship, Helen Hay Whitney Foundation (2008–2011)
- Pathway to Independence Award (K99), NIH (2012–2014)
- Scialog Fellow, Gordon and Betty Moore Foundation (2016–2017)
- New Innovator Award (DP2), NIH (2016–2021)
- Alfred P. Sloan Foundation Research Fellow, Alfred P. Sloan Foundation (2017–2019)
- Investigator, Chan Zuckerberg Biohub (2017–2022)
- Breakthrough Science Initiative Award, Ono Pharma Foundation (2019–2022)
- NSF CAREER Award (2022).[8]
- Eli Lilly Award in Biological Chemistry (2023)[9]
References edit
- ^ a b "Polly Fordyce - Stanford Medicine Profiles". med.stanford.edu.
- ^ a b "The beadnik: Polly Fordyce uses something tiny to do something big". med.stanford.edu.
- ^ Lang MJ, Fordyce PM, Engh AM, Neuman KC, Block SM (November 2004). "Simultaneous, coincident optical trapping and single-molecule fluorescence". Nature Methods. 1 (2): 133–139. doi:10.1038/nmeth714. PMC 1483847. PMID 15782176.
- ^ Fordyce PM, Gerber D, Tran D, Zheng J, Li H, DeRisi JL, Quake SR (September 2010). "De novo identification and biophysical characterization of transcription-factor binding sites with microfluidic affinity analysis". Nature Biotechnology. 28 (9): 970–975. doi:10.1038/nbt.1675. PMC 2937095. PMID 20802496.
- ^ "The Fordyce Lab".
- ^ Markin CJ, Mokhtari DA, Sunden F, Appel MJ, Akiva E, Longwell SA, et al. (July 2021). "Revealing enzyme functional architecture via high-throughput microfluidic enzyme kinetics". Science. 373 (6553): eabf8761. doi:10.1126/science.abf8761. PMC 8454890. PMID 34437092.
- ^ Reardon S (July 2021). "Single chip tests thousands of enzyme mutations at once". Nature. doi:10.1038/d41586-021-02034-3. PMID 34302155. S2CID 236210249.
- ^ "Five Stanford faculty receive NSF CAREER Award". 2 February 2022.
- ^ "Professor Polly Fordyce – Division of Biological Chemistry". Retrieved 2023-01-06.
External links edit
- Polly Fordyce publications indexed by Google Scholar