Pleurocidin is an antimicrobial peptide found in the mucus secreted by the skin of the winter flounder (Pleuronectes americanus). It exhibits broad-spectrum antimicrobial activity.[1] Pleurocidin assumes an amphipathic alpha-helical conformation similar to other linear antimicrobial peptides and may play a role in innate host defence.[2]
| Antimicrobial12 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Antimicrobial12 | ||||||||
| Pfam | PF08107 | ||||||||
| InterPro | IPR012515 | ||||||||
| TCDB | 1.C.62 | ||||||||
| OPM superfamily | 142 | ||||||||
| OPM protein | 1z64 | ||||||||
| |||||||||
Potential Applications edit
Pleurocidin has been noted for its potential use in food safety, in part due to its heat stable properties and clinically demonstrated effectiveness against common food-borne microorganisms.[3]
References edit
- ^ Burrowes, O. J.; Hadjicharalambous, C.; Diamond, G.; Lee, Tung-Ching (2004-04-01). "Evaluation of Antimicrobial Spectrum and Cytotoxic Activity of Pleurocidin for Food Applications". Journal of Food Science. 69 (3): FMS66–FMS71. doi:10.1111/j.1365-2621.2004.tb13373.x. ISSN 1750-3841.
- ^ Cole AM, Weis P, Diamond G (May 1997). "Isolation and characterization of pleurocidin, an antimicrobial peptide in the skin secretions of winter flounder". J. Biol. Chem. 272 (18): 12008–13. doi:10.1074/jbc.272.18.12008. PMID 9115266.
- ^ Burrowes, O. J.; Hadjicharalambous, C.; Diamond, G.; Lee, Tung-Ching (2004-04-01). "Evaluation of Antimicrobial Spectrum and Cytotoxic Activity of Pleurocidin for Food Applications". Journal of Food Science. 69 (3): FMS66–FMS71. doi:10.1111/j.1365-2621.2004.tb13373.x. ISSN 1750-3841.