Pleurocidin is an antimicrobial peptide found in the mucus secreted by the skin of the winter flounder (Pleuronectes americanus). It exhibits broad-spectrum antimicrobial activity.[1] Pleurocidin assumes an amphipathic alpha-helical conformation similar to other linear antimicrobial peptides and may play a role in innate host defence.[2]

Antimicrobial12
Identifiers
SymbolAntimicrobial12
PfamPF08107
InterProIPR012515
TCDB1.C.62
OPM superfamily142
OPM protein1z64
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Potential Applications

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Pleurocidin has been noted for its potential use in food safety, in part due to its heat stable properties and clinically demonstrated effectiveness against common food-borne microorganisms.[3]

References

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  1. ^ Burrowes, O. J.; Hadjicharalambous, C.; Diamond, G.; Lee, Tung-Ching (2004-04-01). "Evaluation of Antimicrobial Spectrum and Cytotoxic Activity of Pleurocidin for Food Applications". Journal of Food Science. 69 (3): FMS66–FMS71. doi:10.1111/j.1365-2621.2004.tb13373.x. ISSN 1750-3841.
  2. ^ Cole AM, Weis P, Diamond G (May 1997). "Isolation and characterization of pleurocidin, an antimicrobial peptide in the skin secretions of winter flounder". J. Biol. Chem. 272 (18): 12008–13. doi:10.1074/jbc.272.18.12008. PMID 9115266.
  3. ^ Burrowes, O. J.; Hadjicharalambous, C.; Diamond, G.; Lee, Tung-Ching (2004-04-01). "Evaluation of Antimicrobial Spectrum and Cytotoxic Activity of Pleurocidin for Food Applications". Journal of Food Science. 69 (3): FMS66–FMS71. doi:10.1111/j.1365-2621.2004.tb13373.x. ISSN 1750-3841.
This article incorporates text from the public domain Pfam and InterPro: IPR012515