Petrillo is an Italian surname. Some people with this surname include:
- Alessio De Petrillo, Italian football player and coach
- Andi Petrillo, Canadian hockey broadcaster
- Ferdinando De Petrillo, Italian boxer who competed in the 1924 Summer Olympics
- James Petrillo (1892–1984), leader of the American Federation of Musicians
- Luigi Petrillo (1903–1964), Italian pentathlete
- Sammy Petrillo (1934–2009), American comedian best known as a Jerry Lewis lookalike
Fictional characters
edit- Sophia Petrillo, character played by Estelle Getty on the TV series The Golden Girls