Personalized mRNA cancer vaccine therapy

Personalized mRNA cancer vaccine therapy is a therapy that uses a personalized cancer vaccine based on mRNA vaccine technology to target existing tumors in patients. As of 2024, number of mRNA cancer vaccines are in clinical trials, of which many are personalized therapies based on engineering mRNA-mediated immune response that targets the patient's particular strain of cancer cells.[1]

Experimental treatments include treatments for pancreatic cancer, head and neck cancers, and melanoma.[2][3][4]

In 2024, the British National Health Service announced that had launched its Cancer Vaccine Launch Pad, a collaboration for trials for the use of personalized mRNA cancer vaccines on its patients.[5]

References

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  1. ^ Yao, Ruhui; Xie, Chunyuan; Xia, Xiaojun (2024-12-31). "Recent progress in mRNA cancer vaccines". Human Vaccines & Immunotherapeutics. 20 (1). doi:10.1080/21645515.2024.2307187. ISSN 2164-5515. PMC 10826636. PMID 38282471.
  2. ^ Kang, Ning; Zhang, Si; Wang, Yuzhuo (2023). "A personalized mRNA vaccine has exhibited potential in the treatment of pancreatic cancer". Holistic Integrative Oncology. 2 (1): 18. doi:10.1007/s44178-023-00042-z. ISSN 2731-4529. PMC 10248956. PMID 37323470.
  3. ^ Shibata, Hirofumi; Zhou, Liye; Xu, Na; Egloff, Ann Marie; Uppaluri, Ravindra (March 2021). "Personalized cancer vaccination in head and neck cancer". Cancer Science. 112 (3): 978–988. doi:10.1111/cas.14784. ISSN 1349-7006. PMC 7935792. PMID 33368875.
  4. ^ Carvalho, Thiago (2023-08-16). "Personalized anti-cancer vaccine combining mRNA and immunotherapy tested in melanoma trial". Nature Medicine. 29 (10): 2379–2380. doi:10.1038/d41591-023-00072-0. PMID 37773210.
  5. ^ Walsh, Fergus (2024-05-30). "Thousands to trial personalised cancer vaccines". BBC News. Retrieved 2024-06-01.
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