Pelubiprofen

Pelubiprofen
Clinical data
Trade names	Pelubi
Legal status
Legal status	Rx in several countries;
Identifiers
	IUPAC name 2-[4-[(E)-(2-Oxocyclohexylidene)methyl]phenyl]propanoic acid;
CAS Number	69956-77-0;
PubChem CID	5282203;
DrugBank	DB12150;
UNII	1619C79FVJ;
CompTox Dashboard (EPA)	DTXSID2048795 ;
Chemical and physical data
Formula	C16H18O3
Molar mass	258.317 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C1=CC=C(C=C1)/C=C/2\CCCCC2=O)C(=O)O;
	InChI InChI=1S/C16H18O3/c1-11(16(18)19)13-8-6-12(7-9-13)10-14-4-2-3-5-15(14)17/h6-11H,2-5H2,1H3,(H,18,19)/b14-10+; Key:AUZUGWXLBGZUPP-GXDHUFHOSA-N;

Pelubiprofen is a nonsteroidal anti-inflammatory drug of the profen class used to treat back pain and osteoarthritis.^[1]

Pelubiprofen was developed in South Korea by Daewon Pharmaceuticals and it is marketed in Korea and Russia,^[2] among other countries.

Research edit

Pelubiprofen is being studied for use in combination with eperisone.^[3]

Because pelubiprofen has low water solubility, development of salt formulations with better solubility are being studied.^[4]

^ "Pelubiprofen". AdisInsight.
^ "Daewon Pharm wins $3 million deal to export Pelubi to Indonesia". Korea Biomedial Review. September 26, 2023.
^ "(Eperisone + pelubiprofen) by Daewon Pharmaceutical for Low Back Pain: Likelihood of Approval". pharmaceutical-technology.com. 5 June 2023.
^ Park, Ji Yeon; Oh, Dong Ho; Park, Sang-Wook; Chae, Bo Ram; Kim, Chul Woo; Han, Sang Heon; Shin, Hyeon Jong; Yeom, Soo Bin; Lee, Da Yeong; Park, Min Kyu; Park, Sang-Eun; Park, Jun-Bom; Lee, Kyung-Tae (2021). "Development of Pelubiprofen Tromethamine with Improved Gastrointestinal Safety and Absorption". Pharmaceutics. 13 (5): 745. doi:10.3390/pharmaceutics13050745. PMC 8158122. PMID 34070062.

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