Panayotov (Bulgarian: Панайотов) is a surname. Notable people with the surname include:
- Aleksandr Panayotov (born 1984), Ukrainian singer-songwriter
- Aleksandr Panayotov Aleksandrov (born 1951), Bulgarian cosmonaut
- Georgi Velikov Panayotov (born 1968), Bulgarian diplomat
- Panayot Panayotov (1930–1996), Bulgarian footballer
- Plamen Panayotov (born 1958), Bulgarian politician and academic
- Rumen Panayotov (born 1954), Bulgarian wheelchair curler
- Vasil Panayotov (born 1990), Bulgarian footballer
- Vladko Panayotov (born 1950), Bulgarian politician