Tyrosine-protein phosphatase non-receptor type 18 is an enzyme that in humans is encoded by the PTPN18 gene.[5][6]

PTPN18
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPTPN18, BDP1, PTP-HSCF, protein tyrosine phosphatase, non-receptor type 18, protein tyrosine phosphatase non-receptor type 18
External IDsOMIM: 606587; MGI: 108410; HomoloGene: 74971; GeneCards: PTPN18; OMA:PTPN18 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001142370
NM_014369

NM_011206

RefSeq (protein)

NP_001135842
NP_055184

NP_035336

Location (UCSC)Chr 2: 130.36 – 130.38 MbChr 1: 34.5 – 34.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-life. This gene was found to be expressed in brain, colon tissues, and several different tumor-derived cell lines. The biological function of this PTP has not yet been determined.[6]

Interactions

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PTPN18 has been shown to interact with PSTPIP1.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000072135Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026126Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kim YW, Wang H, Sures I, Lammers R, Martell KJ, Ullrich A (January 1997). "Characterization of the PEST family protein tyrosine phosphatase BDP1". Oncogene. 13 (10): 2275–9. PMID 8950995.
  6. ^ a b "Entrez Gene: PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)".
  7. ^ Spencer, S; Dowbenko D; Cheng J; Li W; Brush J; Utzig S; Simanis V; Lasky L A (August 1997). "PSTPIP: A Tyrosine Phosphorylated Cleavage Furrow–associated Protein that Is a Substrate for a PEST Tyrosine Phosphatase". J. Cell Biol. 138 (4). UNITED STATES: 845–60. doi:10.1083/jcb.138.4.845. ISSN 0021-9525. PMC 2138048. PMID 9265651.

Further reading

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