PLK3

Polo-like kinase 3 (Drosophila), also known as PLK3, is an enzyme which in humans is encoded by the PLK3 gene.

PLK3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4B6L
Identifiers
Aliases	PLK3, CNK, FNK, PRK, PLK-3, polo like kinase 3
External IDs	OMIM: 602913; MGI: 109604; HomoloGene: 20865; GeneCards: PLK3; OMA:PLK3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p34.1 Start 44,800,377 bp End 44,805,990 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 D1 Start 116,985,852 bp End 116,991,160 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte gastric mucosa ascending aorta left uterine tube gallbladder upper lobe of left lung skin of abdomen Descending thoracic aorta monocyte secondary oocyte Top expressed in perirhinal cortex entorhinal cortex CA3 field granulocyte lactiferous gland choroid plexus of fourth ventricle lip left lobe of liver decidua esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity p53 binding kinase activity protein serine/threonine kinase activity protein binding ATP binding Cellular component cytoplasm centrosome Golgi apparatus microtubule organizing center soma dendrite nucleolus Golgi stack cytoskeleton nucleus nucleoplasm spindle pole Biological process positive regulation of intracellular protein transport regulation of cytokinesis regulation of cell division protein kinase B signaling phosphorylation response to reactive oxygen species mitotic cell cycle checkpoint signaling mitotic G1/S transition checkpoint signaling positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia negative regulation of apoptotic process negative regulation of transcription by RNA polymerase II cellular response to DNA damage stimulus response to osmotic stress protein phosphorylation G2/M transition of mitotic cell cycle cytoplasmic microtubule organization endomitotic cell cycle cell cycle response to radiation Golgi disassembly apoptotic process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest regulation of signal transduction by p53 class mediator positive regulation of chaperone-mediated autophagy G1/S transition of mitotic cell cycle mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1263 12795 Ensembl ENSG00000173846 ENSMUSG00000028680 UniProt Q9H4B4 Q60806 RefSeq (mRNA) NM_004073 NM_013807 NM_001313916 RefSeq (protein) NP_004064 n/a Location (UCSC) Chr 1: 44.8 – 44.81 Mb Chr 4: 116.99 – 116.99 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

Cytokine-inducible kinase is a putative serine/threonine kinase. CNK contains both a catalytic domain and a putative regulatory domain. It may play a role in regulation of cell cycle progression and tumorigenesis.

Interactions

PLK3 has been shown to interact with:

• CDC25C,
• CHEK2, and
• P53.

Further reading

• Li B, Ouyang B, Pan H, Reissmann PT, Slamon DJ, Arceci R, Lu L, Dai W (1996). "Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas". J. Biol. Chem. 271 (32): 19402–8. doi:10.1074/jbc.271.32.19402. PMID 8702627.
• Peng CY, Graves PR, Thoma RS, Wu Z, Shaw AS, Piwnica-Worms H (1997). "Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216". Science. 277 (5331): 1501–5. doi:10.1126/science.277.5331.1501. PMID 9278512.
• Ouyang B, Pan H, Lu L, Li J, Stambrook P, Li B, Dai W (1997). "Human Prk is a conserved protein serine/threonine kinase involved in regulating M phase functions". J. Biol. Chem. 272 (45): 28646–51. doi:10.1074/jbc.272.45.28646. PMID 9353331.
• Kauselmann G, Weiler M, Wulff P, Jessberger S, Konietzko U, Scafidi J, Staubli U, Bereiter-Hahn J, Strebhardt K, Kuhl D (1999). "The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity". EMBO J. 18 (20): 5528–39. doi:10.1093/emboj/18.20.5528. PMC 1171621. PMID 10523297.
• Ouyang B, Li W, Pan H, Meadows J, Hoffmann I, Dai W (1999). "The physical association and phosphorylation of Cdc25C protein phosphatase by Prk". Oncogene. 18 (44): 6029–36. doi:10.1038/sj.onc.1202983. PMID 10557092.
• Shieh SY, Ahn J, Tamai K, Taya Y, Prives C (2000). "The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites". Genes Dev. 14 (3): 289–300. doi:10.1101/gad.14.3.289. PMC 316358. PMID 10673501.
• Dai W, Li Y, Ouyang B, Pan H, Reissmann P, Li J, Wiest J, Stambrook P, Gluckman JL, Noffsinger A, Bejarano P (2000). "PRK, a cell cycle gene localized to 8p21, is downregulated in head and neck cancer". Genes Chromosomes Cancer. 27 (3): 332–6. doi:10.1002/(SICI)1098-2264(200003)27:3<332::AID-GCC15>3.0.CO;2-K. PMID 10679924. S2CID 20642025.
• Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJ (2000). "Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro". Proc. Natl. Acad. Sci. U.S.A. 97 (19): 10389–94. Bibcode:2000PNAS...9710389M. doi:10.1073/pnas.190030497. PMC 27034. PMID 10973490.
• Holtrich U, Wolf G, Yuan J, Bereiter-Hahn J, Karn T, Weiler M, Kauselmann G, Rehli M, Andreesen R, Kaufmann M, Kuhl D, Strebhardt K (2000). "Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages". Oncogene. 19 (42): 4832–9. doi:10.1038/sj.onc.1203845. PMID 11039900. S2CID 25807289.
• Bulavin DV, Higashimoto Y, Popoff IJ, Gaarde WA, Basrur V, Potapova O, Appella E, Fornace AJ (2001). "Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase". Nature. 411 (6833): 102–7. Bibcode:2001Natur.411..102B. doi:10.1038/35075107. PMID 11333986. S2CID 4410763.
• Xie S, Wu H, Wang Q, Cogswell JP, Husain I, Conn C, Stambrook P, Jhanwar-Uniyal M, Dai W (2001). "Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway". J. Biol. Chem. 276 (46): 43305–12. doi:10.1074/jbc.M106050200. PMID 11551930.
• Latonen L, Taya Y, Laiho M (2001). "UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts". Oncogene. 20 (46): 6784–93. doi:10.1038/sj.onc.1204883. PMID 11709713.
• Ahn JY, Li X, Davis HL, Canman CE (2002). "Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain". J. Biol. Chem. 277 (22): 19389–95. doi:10.1074/jbc.M200822200. PMID 11901158.
• Sumara I, Vorlaufer E, Stukenberg PT, Kelm O, Redemann N, Nigg EA, Peters JM (2002). "The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase". Mol. Cell. 9 (3): 515–25. doi:10.1016/S1097-2765(02)00473-2. PMID 11931760.
• Wang Q, Xie S, Chen J, Fukasawa K, Naik U, Traganos F, Darzynkiewicz Z, Jhanwar-Uniyal M, Dai W (2002). "Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity". Mol. Cell. Biol. 22 (10): 3450–9. doi:10.1128/MCB.22.10.3450-3459.2002. PMC 133784. PMID 11971976.
• Bahassi el M, Conn CW, Myer DL, Hennigan RF, McGowan CH, Sanchez Y, Stambrook PJ (2002). "Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways". Oncogene. 21 (43): 6633–40. doi:10.1038/sj.onc.1205850. PMID 12242661. S2CID 24106070.
• Tsvetkov L, Xu X, Li J, Stern DF (2003). "Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody". J. Biol. Chem. 278 (10): 8468–75. doi:10.1074/jbc.M211202200. PMID 12493754.
• Xie S, Wu H, Wang Q, Kunicki J, Thomas RO, Hollingsworth RE, Cogswell J, Dai W (2003). "Genotoxic stress-induced activation of Plk3 is partly mediated by Chk2". Cell Cycle. 1 (6): 424–9. doi:10.4161/cc.1.6.271. PMID 12548019.
• Bahassi el M, Hennigan RF, Myer DL, Stambrook PJ (2004). "Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation". Oncogene. 23 (15): 2658–63. doi:10.1038/sj.onc.1207425. PMID 14968113.