Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide is an enzyme that in humans is encoded by the PIK3C2G gene.[5][6]

PIK3C2G
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPIK3C2G, PI3K-C2-gamma, PI3K-C2GAMMA, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
External IDsOMIM: 609001; MGI: 1203730; HomoloGene: 3362; GeneCards: PIK3C2G; OMA:PIK3C2G - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001288772
NM_001288774
NM_004570

NM_011084
NM_207683

RefSeq (protein)

NP_001275701
NP_001275703
NP_004561

NP_035214
NP_997566

Location (UCSC)Chr 12: 18.24 – 18.65 MbChr 6: 139.56 – 139.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The biological function of this gene has not yet been determined.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000139144Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030228Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Rozycka M, Lu YJ, Brown RA, Lau MR, Shipley JM, Fry MJ (Feb 1999). "cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12". Genomics. 54 (3): 569–74. doi:10.1006/geno.1998.5621. PMID 9878262.
  6. ^ a b "Entrez Gene: PIK3C2G phosphoinositide-3-kinase, class 2, gamma polypeptide".

Further reading

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