Pleckstrin homology-like domain family A member 1 (PHLDA1) is a protein that in humans is encoded by the PHLDA1 gene.[5][6][7]

PHLDA1
Identifiers
AliasesPHLDA1, DT1P1B11, PHRIP, TDAG51, pleckstrin homology like domain family A member 1
External IDsOMIM: 605335; MGI: 1096880; HomoloGene: 7203; GeneCards: PHLDA1; OMA:PHLDA1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007350

NM_009344

RefSeq (protein)

NP_031376

NP_033370

Location (UCSC)Chr 12: 76.03 – 76.03 MbChr 10: 111.34 – 111.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1.[7]

Interactions

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PHLDA1 has been shown to interact with RPL14,[8] EIF3D[8] and PABPC4.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000139289Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020205Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Neef R, Kuske MA, Prols E, Johnson JP (Oct 2002). "Identification of the human PHLDA1/TDAG51 gene: down-regulation in metastatic melanoma contributes to apoptosis resistance and growth deregulation". Cancer Res. 62 (20): 5920–9. PMID 12384558.
  6. ^ Toyoshima Y; Karas M; Yakar S; Dupont J; Lee Helman; LeRoith D (Jun 2004). "TDAG51 mediates the effects of insulin-like growth factor I (IGF-I) on cell survival". J Biol Chem. 279 (24): 25898–904. doi:10.1074/jbc.M400661200. PMID 15037619.
  7. ^ a b "Entrez Gene: PHLDA1 pleckstrin homology-like domain, family A, member 1".
  8. ^ a b c Hinz, T; Flindt S; Marx A; Janssen O; Kabelitz D (May 2001). "Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product". Cell. Signal. 13 (5). England: 345–52. doi:10.1016/S0898-6568(01)00141-3. ISSN 0898-6568. PMID 11369516.

Further reading

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