PGDS protein is a protein that in humans is encoded by the HPGDS gene.[5][6][7][8]

HPGDS
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHPGDS, GSTS, GSTS1-1, PGD2, PGDS, GSTS1, hematopoietic prostaglandin D synthase
External IDsOMIM: 602598; MGI: 1859384; HomoloGene: 113741; GeneCards: HPGDS; OMA:HPGDS - orthologs
EC number2.5.1.18
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014485

NM_019455

RefSeq (protein)

NP_055300

NP_062328

Location (UCSC)Chr 4: 94.3 – 94.34 MbChr 6: 65.09 – 65.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes.[8]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163106Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029919Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kanaoka Y, Ago H, Inagaki E, Nanayama T, Miyano M, Kikuno R, Fujii Y, Eguchi N, Toh H, Urade Y, Hayaishi O (Oct 1997). "Cloning and crystal structure of hematopoietic prostaglandin D synthase". Cell. 90 (6): 1085–95. doi:10.1016/S0092-8674(00)80374-8. PMID 9323136. S2CID 933875.
  6. ^ Mahmud I, Ueda N, Yamaguchi H, Yamashita R, Yamamoto S, Kanaoka Y, Urade Y, Hayaishi O (Dec 1997). "Prostaglandin D synthase in human megakaryoblastic cells". J Biol Chem. 272 (45): 28263–6. doi:10.1074/jbc.272.45.28263. PMID 9353279.
  7. ^ Jowsey IR, Thomson AM, Flanagan JU, Murdock PR, Moore GB, Meyer DJ, Murphy GJ, Smith SA, Hayes JD (Oct 2001). "Mammalian class Sigma glutathione S-transferases: catalytic properties and tissue-specific expression of human and rat GSH-dependent prostaglandin D2 synthases". Biochem J. 359 (Pt 3): 507–16. doi:10.1042/0264-6021:3590507. PMC 1222171. PMID 11672424.
  8. ^ a b "Entrez Gene: PGDS prostaglandin D2 synthase, hematopoietic".

Further reading

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