Wikipedia

PDC-APB

PDC-APB, or 3-pentadecyl-1,2-phenylene bis(4-(4-aminophenyl)butanoate),[1] is a drug candidate under evaluation to determine if it might protect against contact dermatitis caused by urishiol from poison ivy, poison oak, and poison sumac.[2][3][4]

PDC-APB
Clinical data
Other names3-Pentadecyl-1,2-phenylene bis(4-(4-aminophenyl)butanoate; Benzenebutanoic acid, 4-amino-, 1,1'-(3-pentadecyl-1,2-phenylene) ester
Identifiers
  • [2-[4-(4-aminophenyl)butanoyloxy]-3-pentadecylphenyl] 4-(4-aminophenyl)butanoate
CAS Number
PubChem CID
UNII
Chemical and physical data
FormulaC41H58N2O4
Molar mass642.925 g·mol−1
3D model (JSmol)
  • CCCCCCCCCCCCCCCC1=C(C(=CC=C1)OC(=O)CCCC2=CC=C(C=C2)N)OC(=O)CCCC3=CC=C(C=C3)N
  • InChI=1S/C41H58N2O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-20-35-21-17-22-38(46-39(44)23-15-18-33-25-29-36(42)30-26-33)41(35)47-40(45)24-16-19-34-27-31-37(43)32-28-34/h17,21-22,25-32H,2-16,18-20,23-24,42-43H2,1H3
  • Key:VLRZIRYGLUVGGU-UHFFFAOYSA-N

History

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The compound is one of a class of compounds developed through University of Mississippi research[5] by Mahmoud ElSohly, Waseem Gul, and Mohammad Khalid Ashfaq.[1] Work on the compound is ongoing under Hapten Sciences,[6] who licensed the university's research in 2010.[5]

Evaluation as a drug candidate

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The compound has been evaluated in two Phase I clinical trials, and a third Phase I randomized controlled trial, with a secondary objective of evaluating the effect of treatment on urishiol sensitivity, is due to be completed in December 2022.[7][needs update]

See also

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References

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  1. ^ a b US patent 10322103, Elsohly M, Gul M, Ashfaq MK, "Compositions for prevention/prophylactic treatment of poison ivy dermatitis", issued 18 June 2019, assigned to University of Mississippi 
  2. ^ Wallis C (1 September 2021). "A Vaccine against Poison Ivy Misery Is in the Works as Scientists Also Explore New Treatment Paths". Scientific American. Archived from the original on 30 March 2022. Retrieved 27 July 2022.
  3. ^ O'Laughlin F (23 September 2021). "Report: Vaccine that guards against poison ivy misery in the works". WHDH TV. Archived from the original on 23 September 2021. Retrieved 27 July 2022.
  4. ^ Kim Y, Flamm A, ElSohly MA, Kaplan DH, Hage RJ, Hamann CP, Marks JG (2019). "Poison Ivy, Oak, and Sumac Dermatitis: What Is Known and What Is New?". Dermatitis. 30 (3): 183–190. doi:10.1097/DER.0000000000000472. PMID 31045932. S2CID 143423493.
  5. ^ a b Stewart S (18 June 2019). "University Obtains New Patent for Poison Ivy, Oak Vaccine Compound in clinical development with Memphis-based company". RedHillsMSNews.com. Winston County Journal. Archived from the original on 19 June 2019. Retrieved 27 July 2022.
  6. ^ Jefferson R (22 September 2021). "University of Mississippi and Hapten's Poison Ivy Vaccine Development Now in Clinical Trials". The Science Times. Archived from the original on 23 September 2021. Retrieved 27 July 2022.
  7. ^ Doctor V (22 September 2021). "A Prophylactic for Poison Ivy? Phase I Trial Set to Begin". BioSpace. Archived from the original on 2 October 2021. Retrieved 27 July 2022.
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