GC-rich sequence DNA-binding factor homolog is a protein that in humans is encoded by the PAXBP1 gene.[5][6][7]

PAXBP1
Identifiers
AliasesPAXBP1, BM020, C21orf66, FSAP105, GCFC, GCFC1, PAX3 and PAX7 binding protein 1
External IDsOMIM: 617621; MGI: 1914617; HomoloGene: 9604; GeneCards: PAXBP1; OMA:PAXBP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_013329
NM_016631
NM_058191
NM_145328

NM_026110

RefSeq (protein)

NP_037461
NP_057715

NP_080386

Location (UCSC)Chr 21: 32.73 – 32.77 MbChr 16: 90.81 – 90.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Similarity to a transcriptional repressor suggests that this gene's protein product is involved in the regulation of transcription. Alternative splicing of this gene results in three transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.[7]

References

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  1. ^ a b c ENSG00000263141 GRCh38: Ensembl release 89: ENSG00000159086, ENSG00000263141Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022974Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  6. ^ Reymond A, Friedli M, Henrichsen CN, Chapot F, Deutsch S, Ucla C, Rossier C, Lyle R, Guipponi M, Antonarakis SE (Nov 2001). "From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map". Genomics. 78 (1–2): 46–54. doi:10.1006/geno.2001.6640. PMID 11707072.
  7. ^ a b "Entrez Gene: C21orf66 chromosome 21 open reading frame 66".
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Further reading

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