PAS domain-containing serine/threonine-protein kinase is an enzyme that in humans is encoded by the PASK gene.[5][6][7][8]

PASK
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPASK, PASKIN, STK37, PAS domain containing serine/threonine kinase
External IDsOMIM: 607505 MGI: 2155936 HomoloGene: 9038 GeneCards: PASK
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001252119
NM_001252120
NM_001252122
NM_001252124
NM_015148

NM_080850

RefSeq (protein)

NP_001239048
NP_001239049
NP_001239051
NP_001239053
NP_055963

NP_543126

Location (UCSC)Chr 2: 241.11 – 241.15 MbChr 1: 93.24 – 93.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

PAS domains regulate the function of many intracellular signaling pathways in response to both extrinsic and intrinsic stimuli. PASK is an evolutionarily conserved protein present in yeast, flies, and mammals.[supplied by OMIM][8]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115687Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026274Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hofer T, Spielmann P, Stengel P, Stier B, Katschinski DM, Desbaillets I, Gassmann M, Wenger RH (Nov 2001). "Mammalian PASKIN, a PAS-serine/threonine kinase related to bacterial oxygen sensors" (PDF). Biochem Biophys Res Commun. 288 (4): 757–64. doi:10.1006/bbrc.2001.5840. PMID 11688972. Archived from the original (PDF) on 2013-11-02. Retrieved 2018-12-22.
  6. ^ Rutter J, Michnoff CH, Harper SM, Gardner KH, McKnight SL (Aug 2001). "PAS kinase: an evolutionarily conserved PAS domain-regulated serine/threonine kinase". Proc Natl Acad Sci U S A. 98 (16): 8991–6. Bibcode:2001PNAS...98.8991R. doi:10.1073/pnas.161284798. PMC 55361. PMID 11459942.
  7. ^ da Silva Xavier G, Rutter J, Rutter GA (Jun 2004). "Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose". Proc Natl Acad Sci U S A. 101 (22): 8319–24. Bibcode:2004PNAS..101.8319D. doi:10.1073/pnas.0307737101. PMC 420392. PMID 15148392.
  8. ^ a b "Entrez Gene: PASK PAS domain containing serine/threonine kinase".

Further reading edit