Progestin and adipoQ receptor family member 3 (PAQR3), or Raf Kinase Trapping to Golgi apparatus (RKTG) is a protein that in humans is encoded by the PAQR3 gene.[5] It is a member of the progestin and adipoQ receptor (PAQR) family.[6] PAQR3 is predicted to have seven transmembrane helices and to be localized to the Golgi Apparatus.[7][8] It functions as a tumor suppressor by negatively regulating tumor cell proliferation and migration by inhibiting Raf kinase and AKT pathway.[9][10][11][12][13] PAQR3 was also shown to modulate cholesterol homeostasis by anchoring the SCAP/SREBP complex to the Golgi under cholesterol depletion conditions.[14]

PAQR3
Identifiers
AliasesPAQR3, RKTG, progestin and adipoQ receptor family member 3
External IDsOMIM: 614577; MGI: 2679683; HomoloGene: 71077; GeneCards: PAQR3; OMA:PAQR3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001040202
NM_177453
NM_001350105
NM_001350106

NM_198422
NM_001359910
NM_001359913

RefSeq (protein)

NP_001035292
NP_001337034
NP_001337035

NP_940814
NP_001346839
NP_001346842

Location (UCSC)Chr 4: 78.89 – 78.94 MbChr 5: 97.23 – 97.26 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163291Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055725Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yu X, Li Z, Chan MT, Wu WK (2015). "PAQR3: a novel tumor suppressor gene". American Journal of Cancer Research. 5 (9): 2562–2568. PMC 4633890. PMID 26609468.
  6. ^ Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, et al. (September 2005). "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif". Journal of Molecular Evolution. 61 (3): 372–380. Bibcode:2005JMolE..61..372T. doi:10.1007/s00239-004-0375-2. PMID 16044242. S2CID 31473802.
  7. ^ Luo X, Feng L, Jiang X, Xiao F, Wang Z, Feng GS, et al. (September 2008). "Characterization of the topology and functional domains of RKTG". The Biochemical Journal. 414 (3): 399–406. doi:10.1042/BJ20080948. PMID 18547165.
  8. ^ Feng L, Xie X, Ding Q, Luo X, He J, Fan F, et al. (September 2007). "Spatial regulation of Raf kinase signaling by RKTG". Proceedings of the National Academy of Sciences of the United States of America. 104 (36): 14348–14353. Bibcode:2007PNAS..10414348F. doi:10.1073/pnas.0701298104. PMC 1964828. PMID 17724343.
  9. ^ Xie X, Zhang Y, Jiang Y, Liu W, Ma H, Wang Z, et al. (August 2008). "Suppressive function of RKTG on chemical carcinogen-induced skin carcinogenesis in mouse". Carcinogenesis. 29 (8): 1632–1638. doi:10.1093/carcin/bgn139. PMID 18550569.
  10. ^ Zhang Y, Jiang X, Qin X, Ye D, Yi Z, Liu M, et al. (September 2010). "RKTG inhibits angiogenesis by suppressing MAPK-mediated autocrine VEGF signaling and is downregulated in clear-cell renal cell carcinoma". Oncogene. 29 (39): 5404–5415. doi:10.1038/onc.2010.270. PMID 20603618.
  11. ^ Jiang Y, Xie X, Li Z, Wang Z, Zhang Y, Ling ZQ, et al. (April 2011). "Functional cooperation of RKTG with p53 in tumorigenesis and epithelial-mesenchymal transition". Cancer Research. 71 (8): 2959–2968. doi:10.1158/0008-5472.CAN-10-4077. PMID 21385899.
  12. ^ Wang X, Li X, Fan F, Jiao S, Wang L, Zhu L, et al. (November 2012). "PAQR3 plays a suppressive role in the tumorigenesis of colorectal cancers". Carcinogenesis. 33 (11): 2228–2235. doi:10.1093/carcin/bgs245. PMID 22828136.
  13. ^ Fan F, Feng L, He J, Wang X, Jiang X, Zhang Y, et al. (June 2008). "RKTG sequesters B-Raf to the Golgi apparatus and inhibits the proliferation and tumorigenicity of human malignant melanoma cells". Carcinogenesis. 29 (6): 1157–1163. doi:10.1093/carcin/bgn119. PMID 18515281.
  14. ^ Xu D, Wang Z, Zhang Y, Jiang W, Pan Y, Song BL, et al. (August 2015). "PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus". Nature Communications. 6 (1): 8100. Bibcode:2015NatCo...6.8100X. doi:10.1038/ncomms9100. PMC 4560833. PMID 26311497.