OSBPL3

Oxysterol-binding protein-related protein 3 is a protein that in humans is encoded by the OSBPL3 gene.

OSBPL3
Identifiers
Aliases	OSBPL3, ORP-3, ORP3, OSBP3, oxysterol binding protein like 3
External IDs	OMIM: 606732 MGI: 1918970 HomoloGene: 49422 GeneCards: OSBPL3
Gene location (Human) Chr. Chromosome 7 (human) Band 7p15.3 Start 24,796,540 bp End 24,981,634 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 B2.3 Start 50,270,310 bp End 50,433,181 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell amniotic fluid oocyte secondary oocyte left lobe of thyroid gland right lobe of thyroid gland stromal cell of endometrium skin of abdomen lymph node Achilles tendon Top expressed in epithelium of stomach proximal tubule kidney otolith organ utricle ascending aorta adrenal gland duodenum skin of abdomen jejunum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cholesterol binding protein binding lipid binding sterol transporter activity sterol binding Cellular component perinuclear endoplasmic reticulum cell projection cytoplasm endoplasmic reticulum membrane filopodium tip nuclear membrane endoplasmic reticulum plasma membrane nucleus membrane cytosol intracellular membrane-bounded organelle Biological process lipid transport bile acid biosynthetic process sterol transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26031 71720 Ensembl ENSG00000070882 ENSMUSG00000029822 UniProt Q9H4L5 Q9DBS9 RefSeq (mRNA) NM_015550 NM_145320 NM_145321 NM_145322 NM_145323 NM_145324 NM_001163645 NM_027881 NM_001347213 RefSeq (protein) NP_056365 NP_663160 NP_663161 NP_663162 NP_001157117 NP_001334142 NP_082157 Location (UCSC) Chr 7: 24.8 – 24.98 Mb Chr 6: 50.27 – 50.43 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Several transcript variants encoding different isoforms have been identified.

Further reading

• Sanger Centre T, Washington University Genome Sequencing Cente T (Nov 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Laitinen S, Olkkonen VM, Ehnholm C, Ikonen E (Dec 1999). "Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism". Journal of Lipid Research. 40 (12): 2204–11. doi:10.1016/S0022-2275(20)32095-2. PMID 10588946.
• Lehto M, Laitinen S, Chinetti G, Johansson M, Ehnholm C, Staels B, Ikonen E, Olkkonen VM (Aug 2001). "The OSBP-related protein family in humans". Journal of Lipid Research. 42 (8): 1203–13. doi:10.1016/S0022-2275(20)31570-4. PMID 11483621.
• Gregorio-King CC, Collier GR, McMillan JS, Waugh CM, McLeod JL, Collier FM, Kirkland MA (Oct 2001). "ORP-3, a human oxysterol-binding protein gene differentially expressed in hematopoietic cells". Blood. 98 (7): 2279–81. doi:10.1182/blood.V98.7.2279. PMID 11568019.
• Jaworski CJ, Moreira E, Li A, Lee R, Rodriguez IR (Dec 2001). "A family of 12 human genes containing oxysterol-binding domains". Genomics. 78 (3): 185–96. doi:10.1006/geno.2001.6663. PMID 11735225.
• Collier FM, Gregorio-King CC, Apostolopoulos J, Walder K, Kirkland MA (Jan 2003). "ORP3 splice variants and their expression in human tissues and hematopoietic cells". DNA and Cell Biology. 22 (1): 1–9. doi:10.1089/104454903321112442. hdl:10536/DRO/DU:30009437. PMID 12590732.
• Lehto M, Tienari J, Lehtonen S, Lehtonen E, Olkkonen VM (Jan 2004). "Subfamily III of mammalian oxysterol-binding protein (OSBP) homologues: the expression and intracellular localization of ORP3, ORP6, and ORP7". Cell and Tissue Research. 315 (1): 39–57. doi:10.1007/s00441-003-0817-y. PMID 14593528. S2CID 21298003.
• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
• Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (Jun 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Molecular & Cellular Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
• Lehto M, Hynynen R, Karjalainen K, Kuismanen E, Hyvärinen K, Olkkonen VM (Nov 2005). "Targeting of OSBP-related protein 3 (ORP3) to endoplasmic reticulum and plasma membrane is controlled by multiple determinants". Experimental Cell Research. 310 (2): 445–62. doi:10.1016/j.yexcr.2005.08.003. PMID 16143324.