Olfactory receptor family 11 subfamily H member 7 (gene/pseudogene) is a protein that in humans is encoded by the OR11H7 gene. [4]

OR11H7
Identifiers
AliasesOR11H7, OR11H7P, olfactory receptor family 11 subfamily H member 7 (gene/pseudogene)
External IDsMGI: 3030580; GeneCards: OR11H7; OMA:OR11H7 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001348273

NM_146298

RefSeq (protein)

NP_001335202

NP_666410

Location (UCSC)n/aChr 14: 50.88 – 50.89 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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In most humans, OR11H7 is a pseudogene, meaning it does not result in the creation of a functional olfactory receptor protein that binds to specific odorants. Some individuals, however, carry a single-nucleotide polymorphism on one or both chromosomes which transforms it from a pseudogene into an intact gene, and they are significantly more likely to exhibit hyperosmia to the chemical isovaleric acid. Isovaleric acid was shown to be a ligand of OR11H7.[5]

References

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  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000058188Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Entrez Gene: Olfactory receptor family 11 subfamily H member 7 (gene/pseudogene)". Retrieved 2020-04-13.
  5. ^ Menashe I, Abaffy T, Hasin Y, Goshen S, Yahalom V, Luetje CW, Lancet D (October 2007). "Genetic elucidation of human hyperosmia to isovaleric acid". PLOS Biology. 5 (11): e284. doi:10.1371/journal.pbio.0050284. PMC 2043052. PMID 17973576.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.