Obg-like ATPase 1 is an enzyme that in humans is encoded by the OLA1 gene.[5][6] Ola1 belongs to the protein family of Obg-like GTPases but defines an exceptional example of a protein that has evolved altered nucleotide specificity and binds adenosine triphosphate (ATP) with higher affinity than guanosine triphosphate (GTP).[5]

OLA1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesOLA1, DOC45, GBP45, GTBP9, GTPBP9, PTD004, Obg-like ATPase 1, Obg like ATPase 1
External IDsOMIM: 611175; MGI: 1914309; HomoloGene: 5361; GeneCards: OLA1; OMA:OLA1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_013341
NM_001011708
NM_001328688

NM_025942
NM_030091

RefSeq (protein)

NP_001011708
NP_001315617
NP_037473

NP_080218
NP_084367

Location (UCSC)Chr 2: 174.07 – 174.25 MbChr 2: 72.92 – 73.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138430Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027108Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Koller-Eichhorn R, Marquardt T, Gail R, Wittinghofer A, Kostrewa D, Kutay U, Kambach C (Jul 2007). "Human OLA1 defines an ATPase subfamily in the Obg family of GTP-binding proteins". J Biol Chem. 282 (27): 19928–37. doi:10.1074/jbc.M700541200. PMID 17430889.
  6. ^ "Entrez Gene: GTPBP9 GTP-binding protein 9 (putative)".

Further reading

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  • Overview of all the structural information available in the PDB for UniProt: Q9NTK5 (Obg-like ATPase 1) at the PDBe-KB.