O'Beirne may refer to:

  • Frank O'Beirne (1898–1978), farmer, businessman, Irish Republican activist and Fianna Fáil politician in County Sligo
  • Joseph O'Beirne (1900–1980), Irish professional footballer who played as an inside forward
  • Kate O'Beirne (1949–2017), Washington editor of National Review
  • Paul O'Beirne (also known by the pseudonym Apollo 9), American saxophonist notable as a member of Rocket from the Crypt
  • Thomas O'Beirne (1749–1823), Anglican bishop, Bishop of Ossory from 1795 to 1798 when he was translated to Meath

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