Neomycin/polymyxin B/hydrocortisone, sold under the brand Otosporin among others, is a medication used to treat otitis externa (swimmer's ear) and certain eye disorders.[2][3] It consists of the antibiotics neomycin and polymyxin B, and the steroid hydrocortisone.[3] It is used as an ear drop or eye drop.[2][3]
 | |
| Combination of | |
|---|---|
| Neomycin | Antibiotic |
| Polymyxin B | Antibiotic |
| Hydrocortisone | Glucocorticoid |
| Clinical data | |
| Trade names | Otosporin, Cortisporin, others |
| AHFS/Drugs.com | FDA Professional Drug Information |
| Routes of administration | Ear drop |
| ATC code |
|
| Legal status | |
| Legal status | |
| Identifiers | |
| CAS Number | |
| KEGG | |
The most common side effects include itchiness and a skin rash.[4] Other side effects may include dizziness, hives, anaphylaxis, hearing loss, and headache.[2][4] Safety in pregnancy and breastfeeding is unclear.[5] The antibiotics work by killing specific types of bacteria while the steroids work by decreasing inflammation.[6]
The combination was approved for medical use in the United States in 1964.[3] In 2021, it was the 304th most commonly prescribed medication in the United States, with more than 400,000 prescriptions.[7]
History
editCortisporin was developed by Glaxo Wellcome and was approved by the US Food and Drug Administration in 1975. In 1997, the rights were sold to Monarch Pharmaceuticals, a division of King Pharmaceuticals. In 2007, King sold it to JHP Pharmaceuticals. Par Pharmaceutical acquired JHP in 2014. In 2015, Endo International purchased Par.[8]
Society and culture
editEconomics
editIn 2015, the price was $100, and in 2016, it reportedly was selling for $195. A generic version is priced at $144.[8] The drug is owned by Dublin, Ireland-based Endo International..
References
edit- ^ "Neomycin and Polymyxin B Sulfates and Hydrocortisone- neomycin sulfate, polymyxin b sulfate and hydrocortisone solution". DailyMed. 22 April 2019. Retrieved 22 June 2022.
- ^ a b c British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 1164. ISBN 9780857113382.
- ^ a b c d "Neomycin, Polymyxin B, Hydrocortisone Ophthalmic Suspension - FDA prescribing information, side effects and uses". Drugs.com. Retrieved 19 April 2019.
- ^ a b "Hydrocortisone/neomycin/polymyxin b otic Side Effects in Detail". Drugs.com. Retrieved 19 April 2019.
- ^ "Hydrocortisone / neomycin / polymyxin b otic Use During Pregnancy". Drugs.com. Retrieved 19 April 2019.
- ^ "DailyMed - neomycin sulfate, polymyxin b sulfate and hydrocortisone solution". dailymed.nlm.nih.gov. Retrieved 19 April 2019.
- ^ "Neomycin; Polymyxin B; Hydrocortisone - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
- ^ a b David L (4 February 2016). "Martin Shkreli isn't alone in ripping off patients with crazy drug prices". Los Angeles Times. Retrieved 5 February 2016.
