NUDCD3

NudC domain-containing protein 3 is a protein that in humans is encoded by the NUDCD3 gene.

NUDCD3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WGV
Identifiers
Aliases	NUDCD3, NudCL, NudC domain containing 3
External IDs	OMIM: 610296; MGI: 2144158; HomoloGene: 9097; GeneCards: NUDCD3; OMA:NUDCD3 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7p13 Start 44,379,119 bp End 44,490,658 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 A1 Start 6,055,691 bp End 6,150,415 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex right frontal lobe Brodmann area 9 cerebellar hemisphere right hemisphere of cerebellum gastrocnemius muscle stromal cell of endometrium nucleus accumbens islet of Langerhans muscle of thigh Top expressed in dentate gyrus of hippocampal formation granule cell muscle of thigh primary visual cortex superior frontal gyrus dorsomedial hypothalamic nucleus cerebellar cortex piriform cortex temporal muscle subiculum triceps brachii muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding unfolded protein binding Cellular component cytoplasm cytoplasmic dynein complex Biological process protein folding cilium assembly protein localization to pericentriolar material developmental process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23386 209586 Ensembl ENSG00000015676 ENSMUSG00000053838 UniProt Q8IVD9 Q8R1N4 RefSeq (mRNA) NM_015332 NM_173748 NM_001363446 RefSeq (protein) NP_056147 NP_776109 NP_001350375 Location (UCSC) Chr 7: 44.38 – 44.49 Mb Chr 11: 6.06 – 6.15 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

The product of this gene functions to maintain the stability of dynein intermediate chain. Depletion of this gene product results in aggregation and degradation of dynein intermediate chain, mislocalization of the dynein complex from kinetochores, spindle microtubules, and spindle poles, and loss of gamma-tubulin from spindle poles. The protein localizes to the Golgi apparatus during interphase, and levels of the protein increase after the G1/S transition.

Further reading

• Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
• Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51. Bibcode:2001Sci...291.1304V. doi:10.1126/science.1058040. PMID 11181995.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Zhou T, Zimmerman W, Liu X, Erikson RL (2006). "A mammalian NudC-like protein essential for dynein stability and cell viability". Proc. Natl. Acad. Sci. U.S.A. 103 (24): 9039–44. Bibcode:2006PNAS..103.9039Z. doi:10.1073/pnas.0602916103. PMC 1482562. PMID 16754861.