NKTR

NKTR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2HE9
Identifiers
Aliases	NKTR, p104, natural killer cell triggering receptor
External IDs	OMIM: 161565 MGI: 97346 HomoloGene: 122148 GeneCards: NKTR
Gene location (Human)
Chr.	Chromosome 3 (human)
End	42,648,735 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	121,756,843 bp
RNA expression pattern
	Top expressed in
	pylorus; ; cardia; ; caput epididymis; ; optic nerve; ; Achilles tendon; ; corpus epididymis; ; superior surface of tongue; ; visceral pleura; ; corpus callosum; ; superficial temporal artery;
	Top expressed in
	ascending aorta; ; aortic valve; ; cerebellar cortex; ; dorsomedial hypothalamic nucleus; ; habenula; ; superior frontal gyrus; ; pineal gland; ; spermatocyte; ; cerebellar vermis; ; salivary gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	isomerase activity; peptidyl-prolyl cis-trans isomerase activity; cyclosporin A binding; unfolded protein binding;
Cellular component	membrane; nucleoplasm; mitochondrion; cytosol; plasma membrane; nucleus;
Biological process	protein folding; protein peptidyl-prolyl isomerization; protein refolding;
	Sources:Amigo / QuickGO
Orthologs
	4820
	18087
	ENSG00000114857
	ENSMUSG00000032525
	P30414
	P30415
	NM_001012651; NM_005385; NM_001349124; NM_001349125; NM_001349126
	NM_010918
	NP_005376; NP_001336053; NP_001336054; NP_001336055
	NP_035048
	Wikidata
View/Edit Human	View/Edit Mouse

NK-tumor recognition protein is a protein that in humans is encoded by the NKTR gene.^[5]^[6]^[7]

This gene encodes a membrane-anchored protein with a hydrophobic amino terminal domain and a cyclophilin-like PPIase domain. It is present on the surface of natural killer cells and facilitates their binding to targets. Its expression is regulated by IL2 activation of the cells.^[7]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000114857 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032525 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Young HA, Jenkins NA, Copeland NG, Simek S, Lerman MI, Zbar B, Glenn G, Ortaldo JR, Anderson SK (Jul 1993). "Localization of a novel natural killer triggering receptor locus to human chromosome 3p23-p21 and mouse chromosome 9". Genomics. 16 (2): 548–549. doi:10.1006/geno.1993.1229. PMID 8314596.
^ Chambers CA, Gallinger S, Anderson SK, Giardina S, Ortaldo JR, Hozumi N, Roder J (May 1994). "Expression of the NK-TR gene is required for NK-like activity in human T cells". J Immunol. 152 (6): 2669–74. doi:10.4049/jimmunol.152.6.2669. PMID 8144875. S2CID 20265645.
^ ^a ^b "Entrez Gene: NKTR natural killer-tumor recognition sequence".

Further reading edit

Frey JL, Bino T, Kantor RR, et al. (1992). "Mechanism of target cell recognition by natural killer cells: characterization of a novel triggering molecule restricted to CD3- large granular lymphocytes". J. Exp. Med. 174 (6): 1527–1536. doi:10.1084/jem.174.6.1527. PMC 2119033. PMID 1720812.
Rinfret A, Anderson SK (1993). "IL-2 regulates the expression of the NK-TR gene via an alternate RNA splicing mechanism". Mol. Immunol. 30 (14): 1307–1313. doi:10.1016/0161-5890(93)90047-F. PMID 8413330.
Anderson SK, Gallinger S, Roder J, et al. (1993). "A cyclophilin-related protein involved in the function of natural killer cells". Proc. Natl. Acad. Sci. U.S.A. 90 (2): 542–546. Bibcode:1993PNAS...90..542A. doi:10.1073/pnas.90.2.542. PMC 45699. PMID 8421688.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Sakashita E, Tatsumi S, Werner D, et al. (2004). "Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo". Mol. Cell. Biol. 24 (3): 1174–1187. doi:10.1128/MCB.24.3.1174-1187.2004. PMC 321435. PMID 14729963.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Davis TL, Walker JR, Campagna-Slater V, et al. (2010). "Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases". PLOS Biol. 8 (7): e1000439. doi:10.1371/journal.pbio.1000439. PMC 2911226. PMID 20676357.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000114857 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032525 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8314596-5] Young HA, Jenkins NA, Copeland NG, Simek S, Lerman MI, Zbar B, Glenn G, Ortaldo JR, Anderson SK (Jul 1993). "Localization of a novel natural killer triggering receptor locus to human chromosome 3p23-p21 and mouse chromosome 9". Genomics. 16 (2): 548–549. doi:10.1006/geno.1993.1229. PMID 8314596.

[pmid8144875-6] Chambers CA, Gallinger S, Anderson SK, Giardina S, Ortaldo JR, Hozumi N, Roder J (May 1994). "Expression of the NK-TR gene is required for NK-like activity in human T cells". J Immunol. 152 (6): 2669–74. doi:10.4049/jimmunol.152.6.2669. PMID 8144875. S2CID 20265645.

[entrez-7] "Entrez Gene: NKTR natural killer-tumor recognition sequence".

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