NEDD1

Neural precursor cell expressed, developmentally down-regulated 1, also known as Nedd1, is a human gene and encodes the protein NEDD1.

NEDD1
Identifiers
Aliases	NEDD1, GCP-WD, TUBGCP7, neural precursor cell expressed, developmentally down-regulated 1, NEDD1 gamma-tubulin ring complex targeting factor
External IDs	OMIM: 600372; MGI: 97293; HomoloGene: 7439; GeneCards: NEDD1; OMA:NEDD1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q23.1 Start 96,907,224 bp End 96,953,780 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 C2 Start 92,520,608 bp End 92,558,282 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Skeletal muscle tissue of rectus abdominis biceps brachii sperm vastus lateralis muscle deltoid muscle buccal mucosa cell ventricular zone Skeletal muscle tissue of biceps brachii tibialis anterior muscle Top expressed in zygote secondary oocyte primary oocyte atrium right ventricle cardiac muscles digastric muscle genital tubercle myocardium of ventricle triceps brachii muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm microtubule organizing center ciliary basal body centriole cytosol centrosome apical part of cell spindle pole pericentriolar material cytoskeleton Biological process cell division protein localization to centrosome cell cycle G2/M transition of mitotic cell cycle ciliary basal body-plasma membrane docking regulation of G2/M transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 121441 17997 Ensembl ENSG00000139350 ENSMUSG00000019988 UniProt Q8NHV4 P33215 RefSeq (mRNA) NM_001135175 NM_001135176 NM_001135177 NM_152905 NM_008682 RefSeq (protein) NP_001128647 NP_001128648 NP_001128649 NP_690869 NP_032708 Location (UCSC) Chr 12: 96.91 – 96.95 Mb Chr 10: 92.52 – 92.56 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

NEDD1 is localized in the centrosome and it plays a role in mitosis through its interaction with γ-tubulin. WD40 repeats are located in the amino-terminal of the protein and are responsible for NEDD1 localization in the centrosome, and the carboxy-terminal amino acids are needed for interactions with γ-tubulin. Depletion of NEDD1 causes impaired centrosome and chromatin microtubules assembly that results in the failure of microtubule nucleation and prevents proper spindle formation.

Further reading

• Pinyol R, Scrofani J, Vernos I (2012). "The role of NEDD1 phosphorylation by Aurora A in chromosomal microtubule nucleation and spindle function". Curr. Biol. 23 (2): 143–9. doi:10.1016/j.cub.2012.11.046. hdl:10230/23504. PMID 23273898.
• Sdelci S, Schütz M, Pinyol R, et al. (2012). "Nek9 phosphorylation of NEDD1/GCP-WD contributes to Plk1 control of γ-tubulin recruitment to the mitotic centrosome". Curr. Biol. 22 (16): 1516–23. Bibcode:2012CBio...22.1516S. doi:10.1016/j.cub.2012.06.027. PMID 22818914.
• Haren L, Remy MH, Bazin I, et al. (2006). "NEDD1-dependent recruitment of the gamma-tubulin ring complex to the centrosome is necessary for centriole duplication and spindle assembly". J. Cell Biol. 172 (4): 505–15. doi:10.1083/jcb.200510028. PMC 2063671. PMID 16461362.
• Lüders J, Patel UK, Stearns T (2006). "GCP-WD is a gamma-tubulin targeting factor required for centrosomal and chromatin-mediated microtubule nucleation". Nat. Cell Biol. 8 (2): 137–47. doi:10.1038/ncb1349. PMID 16378099. S2CID 27587898.
• Jung SY, Malovannaya A, Wei J, et al. (2005). "Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes". Mol. Endocrinol. 19 (10): 2451–65. doi:10.1210/me.2004-0476. PMID 16051665. S2CID 24948585.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Takai S, Yoshida Y, Noda M, et al. (1995). "Assignment of the developmentally regulated gene NEDD1 to human chromosome 12q22 by fluorescence in situ hybridization". Hum. Genet. 95 (1): 96–8. doi:10.1007/BF00225082. PMID 7814034. S2CID 902030.