NADH:ubiquinone reductase (Na+-transporting)

NADH:ubiquinone reductase (Na+-transporting) (EC 1.6.5.8 is an enzyme with systematic name NADH:ubiquinone oxidoreductase (Na+-translocating). In bacteria, three different types of respiratory NADH:quinone oxidoreductases (NQr) have been described: the electrogenic complex I, also called NDH I in bacteria, the non-electrogenic NADH:quinone oxidoreductases (NDH II), and the Na+-translocating NADH:quinone oxidoreductases Na+-NQr. The common function of these transmembrane enzymes in respiration is to oxidize NADH using ubiquinone (Q) as electron acceptor. The net reaction thus yields ubiquinol (QH2), the reducing substrate of enzyme complexes further along the respiratory chain, and NAD+, which is used as oxidizing agent in numerous cellular processes.[1]

Na(+)-translocating NADH-quinone reductase
Identifiers
SymbolNQR
PfamPF03116
TCDB3.D.5
OPM superfamily372
OPM protein4pbv
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
NADH:ubiquinone reductase (Na+-transporting)
Identifiers
EC no.1.6.5.8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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NCBIproteins
NADH + H+ + ubiquinone + n Na+in → NAD+ + ubiquinol + n Na+out

The enzyme is iron-sulfur flavoprotein.

References

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  1. ^ Fritz G, Steuber J (2016). "Chapter 11: Sodium as Coupling Cation in Respiratory Energy Conversion". In Astrid S, Helmut S, Roland S (eds.). The Alkali Metal Ions: Their Role in Life. Metal Ions in Life Sciences. Vol. 16. Springer. pp. 349–390. doi:10.1007/978-3-319-21756-7_11. PMID 26860307.
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