N-methyl-L-amino-acid oxidase

In enzymology, a N-methyl-L-amino-acid oxidase (EC 1.5.3.2) is an enzyme that catalyzes the chemical reaction

N-methyl-L-amino-acid oxidase
Identifiers
EC no.1.5.3.2
CAS no.9029-23-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
an N-methyl-L-amino acid + H2O + O2 an L-amino acid + formaldehyde + H2O2

The 3 substrates of this enzyme are N-methyl-L-amino acid, H2O, and O2, whereas its 3 products are L-amino acid, formaldehyde, and H2O2.

It has 2 cofactors: FAD, and Flavoprotein.

Nomenclature

edit

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with oxygen as acceptor. The systematic name of this enzyme class is N-methyl-L-amino-acid:oxygen oxidoreductase (demethylating). Other names in common use include N-methylamino acid oxidase, and demethylase.

References

edit

Further reading

edit
  • Moritani M (1952). "Demethylase. IV. Kinetics and reaction mechanism". Hukuoka Acta Med. 43: 651–658.
  • Moritani M (1952). "Demethylase. V. Specificity and its relation to amino acid oxidase". Hukuoka Acta Med. 43: 731–735.
  • Moritani M, Tung TC, Fujii S, Mito H, Izumiya N, Kenmochi K, Hirohata R (August 1954). "Specificity of rabbit kidney demethylase". The Journal of Biological Chemistry. 209 (2): 485–92. PMID 13192101.