Myristoyl-CoA 11-(E) desaturase

In enzymology, a myristoyl-CoA 11-(E) desaturase (EC 1.14.99.31) is an enzyme that catalyzes the chemical reaction

myristoyl-CoA 11-(E) desaturase
Identifiers
EC no.1.14.99.31
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
myristoyl-CoA + NAD(P)H + H+ + O2 (E)-11-tetradecenoyl-CoA + NAD(P)+ + 2 H2O

The 5 substrates of this enzyme are myristoyl-CoA, NADH, NADPH, H+, and O2, whereas its 4 products are (E)-11-tetradecenoyl-CoA, NAD+, NADP+, and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O miscellaneous. The systematic name of this enzyme class is n-tetradecanoyl-CoA,NAD(P)H:O2 oxidoreductase [11-(E) desaturating].

References

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  • Navaro I, Font I, Fabrias G, Camps F (1997). "Stereospecificity of the (E)- and (Z)-11 myristoyl desaturases in the biosynthesis of Spodoptera littoralis sex pheromone". J. Am. Chem. Soc. 119 (46): 11335–11336. doi:10.1021/ja972577v.