Wikipedia

Muzlifah Haniffa

Muzlifah Haniffa is a Malaysian dermatologist and immunologist who focuses on the development of the immune system and the use of single-cell techniques to understand biology. Haniffa is a professor and Wellcome Trust Senior Research Fellow in the Faculty of Medical Sciences at Newcastle University.[1][2]

Muzlifah Haniffa
Presenting at the Wellcome Trust Sanger Institute in 2020
Born
Penang, Malaysia
Alma materNewcastle University
Scientific career
FieldsDermatology, Immunology, Bioinformatics

Early life and education edit

Haniffa was born in Penang, Malaysia.[3] Her interests in science as a child were piqued initially by space, but later she decided to pursue a career as a clinical scientist.[2] Haniffa studied at Tunku Kurshiah College, Seremban and moved to the UK in the 1990s.[4] Haniffa graduated BSc, MBBCh from the University of Wales College of Medicine in 1999. She became a member of the Royal College of Physicians in 2002. In 2007, she earned a diploma in epidemiology from the London School of Hygiene & Tropical Medicine.[1] She completed her PhD from Newcastle University in 2009 and completed her clinical dermatology training in 2010.[1] She was runner-up for the 2009 Sue McCarthy Prize from the Medical Research Council.[1]

Career edit

In 2013 the European Society for Dermatology Research awarded Haniffa a Silver Award for her research.[1] She was shortlisted for the 2016 North Eastern Woman Entrepreneur of the Year awards in the STEM category.[5] In 2016 her research into the functions of white blood cells was boosted by a £200,000 fellowship by the Lister Institute of Preventive Medicine.[3][2][4] Professor Chris Day, serving as vice-chancellor of the medical faculty, congratulated Haniffa on her achievement, saying:[4]

Professor Haniffa is one of the outstanding clinician scientists of her generation and has rapidly, in her short career, established an international reputation in her field

— Chris Day

Haniffa's work on the immune system has included discovering that a population of what was considered dendritic cells (defined by the presence of CD14) in human skin were in fact macrophages, and studies demonstrating that a subset of dendritic cells exist in mice which can activate T helper 17 cells against a fungal infection.[6][7] Haniffa was awarded the 2018 Early Career Prize in Allerlology by the 5th European Congress on Immunology.[8]

Haniffa is a member of the Human Cell Atlas, which aims to characterise all cells in the human body using single-cell transcriptomic techniques, alongside Sarah Teichmann, Fiona Powrie, Ashley Moffett, and others.[9][10][11] In 2018 her lab contributed to the discovery of the major subset of kidney cells which become mutated and give rise to kidney cancers. This was accomplished by matching the biological make-up of kidney carcinoma cells to given healthy kidney cells.[12][13][14] This was followed by a single-cell study of the placenta which discovered new cell sub-types in the decidua, informing understanding of how the maternal and fetal immune systems interact with each other and avoid miscarriage or pre-eclampsia.[15][16][17] The study used 70,000 cells and tissue from the Human Developmental Biology Resource.[15] In addition Haniffa and collaborators have published single-cell studies on the innate and adaptive immune system, including regulatory T cells, dendritic cells, and monocytes.[18][19][20][21] In 2019 the Chan Zuckerberg Initiative announced that it was investing $68 million in grants into furthering the Human Cell Atlas, including awards for Haniffa to study the immune system and liver during ageing in single-cell detail.[22][23][24]

She is a committee member of the British Society for Investigative Dermatology, who had awarded Haniffa a Junior Investigator Prize in 2012.[1][25]

References edit

  1. ^ a b c d e f "Professor Muzlifah Haniffa". Newcastle University. Retrieved 10 June 2022.
  2. ^ a b c Albakri, Danial. "Penang-born scientist receives RM1.09mil for work on white blood cells - Nation | The Star Online". www.thestar.com.my. Retrieved 2019-07-14.
  3. ^ a b Reporters, F. M. T. (2016-09-11). "Penang-born scientist gets RM1m UK research award". Free Malaysia Today. Retrieved 2019-07-14.
  4. ^ a b c Ruxyn, Tang (2016-09-08). "This Malaysian Received A Prestigious Research Prize For Her Outstanding Scientific Work". SAYS.com. Retrieved 2019-07-14.
  5. ^ Whitfield, Graeme (2016-10-05). "Top businesswomen shortlisted in North East Woman Entrepreneur of the Year Awards". nechronicle. Retrieved 2019-07-14.
  6. ^ "Discovery of a new class of white blood cells uncovers target for better vaccine design". ScienceDaily. Retrieved 2019-07-14.
  7. ^ Haniffa, Muzlifah; Collin, Matthew; Ginhoux, Florent; Bigley, Venetia; Poidinger, Michael; Duan, Kaibo; Wasan, Pavandip Singh; Larbi, Anis; Miranda-Saavedra, Diego (2014-09-18). "Human Dermal CD14+ Cells Are a Transient Population of Monocyte-Derived Macrophages". Immunity. 41 (3): 465–477. doi:10.1016/j.immuni.2014.08.006. ISSN 1074-7613. PMC 4175180. PMID 25200712.
  8. ^ "Award Ceremonies". ECI 2018. Retrieved 2019-07-14.
  9. ^ "Human Cell Atlas: we're funding scientists at six UK research institutes | Wellcome". wellcome.ac.uk. Retrieved 2019-07-14.
  10. ^ "Human Cell Atlas Takes First Steps Towards Understanding Human Development". Cell Science from Technology Networks. Retrieved 2019-07-14.
  11. ^ Regev, Aviv; Teichmann, Sarah A; Lander, Eric S; Amit, Ido; Benoist, Christophe; Birney, Ewan; Bodenmiller, Bernd; Campbell, Peter; Carninci, Piero (2017-12-05). "The Human Cell Atlas". eLife. 6. doi:10.7554/eLife.27041. ISSN 2050-084X. PMC 5762154. PMID 29206104.
  12. ^ "New hope for patients with kidney cancer". The Northern Echo. Retrieved 2019-07-14.
  13. ^ Behjati, Sam; Clatworthy, Menna; Teichmann, Sarah A.; Haniffa, Muzlifah; Coleman, Nicholas; Sebire, Neil; Stewart, Grant D.; Warren, Anne Y.; Lindsay, Susan (2018-08-10). "Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors". Science. 361 (6402): 594–599. Bibcode:2018Sci...361..594Y. doi:10.1126/science.aat1699. ISSN 0036-8075. PMC 6104812. PMID 30093597.
  14. ^ "Single-Cell Transcriptome Atlas Elucidates Features Shared by Cancerous, Normal Kidneys". GenomeWeb. 9 August 2018. Retrieved 2019-07-14.
  15. ^ a b "Human cell atlas study reveals maternal immune system modifications in early pregnancy: Cell map of healthy pregnancy could also help understand miscarriages or pre-eclampsia". ScienceDaily. Retrieved 2019-07-14.
  16. ^ Teichmann, Sarah A.; Moffett, Ashley; Haniffa, Muzlifah; Stubbington, Michael J. T.; Wright, Gavin J.; Bulmer, Judith N.; Rowitch, David H.; Filby, Andrew; Lisgo, Steve (November 2018). "Single-cell reconstruction of the early maternal–fetal interface in humans". Nature. 563 (7731): 347–353. Bibcode:2018Natur.563..347V. doi:10.1038/s41586-018-0698-6. ISSN 1476-4687. PMC 7612850. PMID 30429548. S2CID 53302717.
  17. ^ "The Very First Human Cell Atlas Study of Early Pregnancy". Cell Science from Technology Networks. Retrieved 2019-07-14.
  18. ^ Miragaia, Ricardo J.; Gomes, Tomás; Chomka, Agnieszka; Jardine, Laura; Riedel, Angela; Hegazy, Ahmed N.; Whibley, Natasha; Tucci, Andrea; Chen, Xi (February 2019). "Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation". Immunity. 50 (2): 493–504.e7. doi:10.1016/j.immuni.2019.01.001. PMC 6382439. PMID 30737144.
  19. ^ See, Peter; Dutertre, Charles-Antoine; Chen, Jinmiao; Günther, Patrick; McGovern, Naomi; Irac, Sergio Erdal; Gunawan, Merry; Beyer, Marc; Händler, Kristian (2017-06-09). "Mapping the human DC lineage through the integration of high-dimensional techniques". Science. 356 (6342): eaag3009. doi:10.1126/science.aag3009. ISSN 0036-8075. PMC 7611082. PMID 28473638. S2CID 206651407.
  20. ^ Villani, Alexandra-Chloé; Satija, Rahul; Reynolds, Gary; Sarkizova, Siranush; Shekhar, Karthik; Fletcher, James; Griesbeck, Morgane; Butler, Andrew; Zheng, Shiwei (2017-04-21). "Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors". Science. 356 (6335): eaah4573. doi:10.1126/science.aah4573. ISSN 0036-8075. PMC 5775029. PMID 28428369.
  21. ^ Hagai, Tzachi; Chen, Xi; Miragaia, Ricardo J.; Rostom, Raghd; Gomes, Tomás; Kunowska, Natalia; Henriksson, Johan; Park, Jong-Eun; Proserpio, Valentina (November 2018). "Gene expression variability across cells and species shapes innate immunity". Nature. 563 (7730): 197–202. Bibcode:2018Natur.563..197H. doi:10.1038/s41586-018-0657-2. hdl:1822/56906. ISSN 0028-0836. PMC 6347972. PMID 30356220.
  22. ^ www-core (webteam). "Chan Zuckerberg Initiative boosts Human Cell Atlas research at the Sanger Institute". www.sanger.ac.uk. Retrieved 2019-07-14.
  23. ^ "An Integrated Map of the Immune System in Humans Across Tissues and Ages". Chan Zuckerberg Initiative. Retrieved 2019-07-14.
  24. ^ "A Reference Cell Atlas of Human Liver Diversity Over a Lifespan". Chan Zuckerberg Initiative. Retrieved 2019-07-14.
  25. ^ "Professor Muzlifah Haniffa • British Society for Investigative Dermatology". British Society for Investigative Dermatology. Retrieved 2019-07-14.
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