Monocarboxylate transporter 3

Monocarboxylate transporter 3 (MCT3) also known as solute carrier family 16 member 8 is a protein that in humans is encoded by the SLC16A8 gene.[5] MCT is a proton-coupled monocarboxylate transporter. It catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. It also functions as high-affinity pyruvate transporter.

SLC16A8
Identifiers
AliasesSLC16A8, MCT3, REMP, solute carrier family 16 member 8
External IDsOMIM: 610409; MGI: 1929519; HomoloGene: 75006; GeneCards: SLC16A8; OMA:SLC16A8 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_013356
NM_001394131

NM_020516

RefSeq (protein)

NP_037488

NP_065262

Location (UCSC)Chr 22: 38.08 – 38.08 MbChr 15: 79.14 – 79.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Expression of SLC16A8 is confined to the retinal pigment epithelium and choroid plexus epithelia, where it is located on the basal membrane in contrast to MCT1 which is found on the apical membrane.

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100156Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032988Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Garcia CK, Goldstein JL, Pathak RK, Anderson RG, Brown MS (Mar 1994). "Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle". Cell. 76 (5): 865–73. doi:10.1016/0092-8674(94)90361-1. PMID 8124722. S2CID 22137883.

Further reading

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