Mitochondrial ribosomal protein L28

39S ribosomal protein L28, mitochondrial is a protein that in humans is encoded by the MRPL28 gene.[5][6][7]

MRPL28
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPL28, MAAT1, p15, mitochondrial ribosomal protein L28
External IDsOMIM: 604853; MGI: 1915861; HomoloGene: 4693; GeneCards: MRPL28; OMA:MRPL28 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006428

NM_024227

RefSeq (protein)

NP_006419

NP_077189

Location (UCSC)Chr 16: 0.37 – 0.37 MbChr 17: 26.34 – 26.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein, a part of which was originally isolated by its ability to recognize tyrosinase in an HLA-A24-restricted fashion.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000086504Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024181Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Robbins PF, el-Gamil M, Li YF, Topalian SL, Rivoltini L, Sakaguchi K, Appella E, Kawakami Y, Rosenberg SA (Jun 1995). "Cloning of a new gene encoding an antigen recognized by melanoma-specific HLA-A24-restricted tumor-infiltrating lymphocytes". J Immunol. 154 (11): 5944–50. doi:10.4049/jimmunol.154.11.5944. PMID 7751637.
  6. ^ Koc EC, Burkhart W, Blackburn K, Moyer MB, Schlatzer DM, Moseley A, Spremulli LL (Nov 2001). "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present". J Biol Chem. 276 (47): 43958–69. doi:10.1074/jbc.M106510200. PMID 11551941.
  7. ^ a b "Entrez Gene: MRPL28 mitochondrial ribosomal protein L28".

Further reading

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