In molecular biology mir-601 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
| mir-601 | |
|---|---|
| Identifiers | |
| Symbol | mir-601 |
| Rfam | RF01006 |
| miRBase family | MIPF0000522 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota; |
| PDB structures | PDBe |
Molecular pathway regulation
editmiR-601 has been found to affect a number of different cell signalling pathways, more specifically bringing about downregulation of Fas-induced apoptosis and NF-kappa B signalling. There is additionally upregulation of the actin cytoskeleton and increased negative regulation of translational initiation by miR-601.[1] The importance of NF-kappa B in tumour cell proliferation and enhanced survival means that miR-601 mimics may hold a lot of promise for prevention or treatment of carcinogenesis.
miR-602 has further been linked to the development and progression of gastric cancer, with levels significantly upregulated compared with normal gastric tissue.[2]
See also
editReferences
edit- ^ Ohdaira H, Nakagawa H, Yoshida K (2009). "Profiling of molecular pathways regulated by microRNA 601". Computational Biology and Chemistry. 33 (6): 429–33. doi:10.1016/j.compbiolchem.2009.09.003. PMID 19889580.
- ^ Yao Y, Suo AL, Li ZF, Liu LY, Tian T, Ni L, et al. (2009). "MicroRNA profiling of human gastric cancer". Molecular Medicine Reports. 2 (6): 963–70. doi:10.3892/mmr_00000199. PMID 21475928.
External links
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