Miltiradiene synthase (EC 4.2.3.131, SmMDS, SmiKSL) is an enzyme with systematic name (+)-copaly-diphosphate diphosphate-lyase (cyclizing, miltiradiene-forming).[1][2] This enzyme catalyses the following chemical reaction
| Miltiradiene synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.2.3.131 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- (+)-copalyl diphosphate miltiradiene + diphosphate
This enzyme is isolated from the plant Selaginella moellendorffii.
References
edit- ^ Gao W, Hillwig ML, Huang L, Cui G, Wang X, Kong J, Yang B, Peters RJ (November 2009). "A functional genomics approach to tanshinone biosynthesis provides stereochemical insights". Organic Letters. 11 (22): 5170–3. doi:10.1021/ol902051v. PMC 2776380. PMID 19905026.
- ^ Sugai Y, Ueno Y, Hayashi K, Oogami S, Toyomasu T, Matsumoto S, Natsume M, Nozaki H, Kawaide H (December 2011). "Enzymatic (13)C labeling and multidimensional NMR analysis of miltiradiene synthesized by bifunctional diterpene cyclase in Selaginella moellendorffii". The Journal of Biological Chemistry. 286 (50): 42840–7. doi:10.1074/jbc.m111.302703. PMC 3234827. PMID 22027823.
External links
edit- Miltiradiene+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
