Middleton, County Durham, may refer to several places in County Durham, England:
- Middleton, Hartlepool, a town in Hartlepool
- Middleton-in-Teesdale, a small market town situated on the north side of Teesdale
- Middleton One Row, a village in the borough of Darlington
- Middleton St George, a village in the borough of Darlington
This disambiguation page lists articles about distinct geographical locations with the same name.
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