Methylphenyltetrahydropyridine N-monooxygenase

Methylphenyltetrahydropyridine N-monooxygenase (EC 1.13.12.11) is an enzyme with systematic name 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine:oxygen N-oxidoreductase.[1] This enzyme catalyses the following chemical reaction

Methylphenyltetrahydropyridine N-monooxygenase
Identifiers
EC no.1.13.12.11
CAS no.37256-73-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
PubMedarticles
NCBIproteins
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + O2 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine N-oxide + methanol

Methylphenyltetrahydropyridine N-monooxygenase is a flavoprotein.

References

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  1. ^ Chiba K, Kubota E, Miyakawa T, Kato Y, Ishizaki T (September 1988). "Characterization of hepatic microsomal metabolism as an in vivo detoxication pathway of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice". The Journal of Pharmacology and Experimental Therapeutics. 246 (3): 1108–15. PMID 3262153.
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