Methylamine-corrinoid protein Co-methyltransferase

Methylamine-corrinoid protein Co-methyltransferase (EC 2.1.1.248, mtmB (gene), monomethylamine methyltransferase) is an enzyme with the systematic name monomethylamine:5-hydroxybenzimidazolylcobamide Co-methyltransferase.[1][2][3] This enzyme catalyzes the following chemical reaction:

Methylamine-corrinoid protein Co-methyltransferase
Identifiers
EC no.2.1.1.248
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins
Methylamine + [Co(I) methylamine-specific corrinoid protein] [methyl-Co(III) methylamine-specific corrinoid protein] + Ammonia

This enzyme is involved in methanogenesis from methylamine.

References

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  1. ^ Burke SA, Krzycki JA (June 1997). "Reconstitution of Monomethylamine:Coenzyme M methyl transfer with a corrinoid protein and two methyltransferases purified from Methanosarcina barkeri". The Journal of Biological Chemistry. 272 (26): 16570–7. doi:10.1074/jbc.272.26.16570. PMID 9195968.
  2. ^ Burke SA, Lo SL, Krzycki JA (July 1998). "Clustered genes encoding the methyltransferases of methanogenesis from monomethylamine". Journal of Bacteriology. 180 (13): 3432–40. PMC 107300. PMID 9642198.
  3. ^ Krzycki JA (October 2004). "Function of genetically encoded pyrrolysine in corrinoid-dependent methylamine methyltransferases". Current Opinion in Chemical Biology. 8 (5): 484–91. doi:10.1016/j.cbpa.2004.08.012. PMID 15450490.
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