Metazosin is an antihypertensive α1-adrenergic receptor antagonist.[1][2]
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Names | |
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IUPAC name
1-[4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-2-methoxypropan-1-one
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Other names
Kenosin
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Identifiers | |
3D model (JSmol)
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ChemSpider | |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C18H25N5O4 | |
Molar mass | 375.429 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Synthesis
edit- 2-methoxypropionylchloride [56680-75-2] (2)
- 2-Methoxy-1-(piperazin-1-yl)propan-1-one [95550-01-9] (3)
- 4-Amino-2-chloro-6,7-dimethoxyquinazoline [23680-84-4] (4)
References
edit- ^ Trcka, V; König, J; Mácová, S; Smíd, M; Helfert, I; Votavová, M; Remesová, J; Nezádalová, E (1990). "Pharmacology of a new antihypertensive agent, metazosin (Kenosin)". Ceskoslovenska Farmacie. 39 (6): 266–74. PMID 1981860.
- ^ Lapka, R; Rejholec, V; Sechser, T; Peterková, M; Smíd, M (1989). "Interspecies pharmacokinetic scaling of metazosin, a novel alpha-adrenergic antagonist". Biopharmaceutics & Drug Disposition. 10 (6): 581–9. doi:10.1002/bdd.2510100607. PMID 2575403.
- ^ Smd, M.; Trcka, V.; Knig, J.; METAZOSIN. Drugs Fut 1990, 15, 7, 680.
- ^ DE3419223, idem Jan Dipl Ing Koenig, Miroslav Dipl Ing Rajsner,Vaclav Trcka, Svetluse Macova, U.S. patent 4,775,673 (1984 to Spofa Spojene Tovarny Pro Zdra).