In enzymology, a mannose-6-phosphate 6-reductase (EC 1.1.1.224) is an enzyme that catalyzes the chemical reaction
| mannose-6-phosphate 6-reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.224 | ||||||||
| CAS no. | 88747-79-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
- D-mannitol 1-phosphate + NADP+ D-mannose 6-phosphate + NADPH + H+
Thus, the two substrates of this enzyme are D-mannitol 1-phosphate and NADP+, whereas its 3 products are D-mannose 6-phosphate, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-mannitol-1-phosphate:NADP+ 6-oxidoreductase. Other names in common use include NADPH-dependent mannose 6-phosphate reductase, mannose-6-phosphate reductase, 6-phosphomannose reductase, NADP+-dependent mannose-6-P:mannitol-1-P oxidoreductase, NADPH-dependent M6P reductase, and NADPH-mannose-6-P reductase.
References edit
- Rumpho ME, Edwards GE, Loescher WH (1983). "A pathway for photosynthetic carbon flow to mannitol in celery leaves: Activity and localization of key enzymes". Plant Physiol. 73 (4): 869–873. doi:10.1104/pp.73.4.869. PMC 1066569. PMID 16663332.
