Mancini (Italian pronunciation: [manˈtʃiːni]) is a surname of Italian origin which, etymologically, comes from the Italian adjective mancino, which literally means "left handed".

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  • Lucy Mancini, a character in The Godfather. She was the Maid of Honor at Connie Corleone's wedding and had an affair with Sonny Corleone; in The Godfather Part III, it is revealed she had conceived a child, Vincent Santino Mancini
  • Michael Mancini, character on Melrose Place (1992–1999) (2009)
  • Vincent Mancini, illegitimate child of Sonny Corleone and Lucy Mancini, featured in The Godfather Part III

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