Man Up may refer to:
Look up man up in Wiktionary, the free dictionary.
- Man Up (album), a 2008 album by The Blue Van
- Man Up (film), a 2015 film
- Man Up, a development programme fostered by Destiny Church in New Zealand
- ROH Man Up, a professional-wrestling event
- Man Up!, a 2011 sitcom
- WVBZ, a radio station licensed to Clemmons, North Carolina, United States and called 105.7 Man Up since 2015
- "Man Up", a song from the Broadway musical The Book of Mormon
- "Man Up", a song by Nikki Lane from the album All or Nothin'