Maltezos (Greek: Μαλτέζος) is a Greek surname literally meaning "Maltese". Notable people with the surname include:
- Christos Maltezos (1908–1938), Greek communist murdered during the Metaxas regime
- Chryssa Maltezou (born 1941), Greek historian
- Yiannis Maltezos (1915 - 1987), Greek painter and visual artist
- Yvonni Maltezou (born 1949), Greek theater, television and film actress