Major League Baseball expansion could refer to:
- 1961 Major League Baseball expansion, which added the Los Angeles Angels and Washington Senators
- 1962 Major League Baseball expansion, which added the Houston Colt .45s and New York Mets
- 1969 Major League Baseball expansion, which added the Kansas City Royals, Montreal Expos, San Diego Padres, and Seattle Pilots
- 1977 Major League Baseball expansion, which added the Seattle Mariners and Toronto Blue Jays
- 1993 Major League Baseball expansion, which added the Colorado Rockies and Florida Marlins
- 1998 Major League Baseball expansion, which added the Arizona Diamondbacks and Tampa Bay Devil Rays
- Potential Major League Baseball expansion