Macc1, met transcriptional regulator

MACC1, MET transcriptional regulator is a protein that in humans is encoded by the MACC1 gene.[5]

MACC1
Identifiers
AliasesMACC1, 7A5, SH3BP4L, metastasis associated in colon cancer 1, MET transcriptional regulator, MET transcriptional regulator MACC1
External IDsOMIM: 612646; MGI: 2685113; HomoloGene: 18813; GeneCards: MACC1; OMA:MACC1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_182762

NM_001163136

RefSeq (protein)

NP_877439

NP_001156608

Location (UCSC)Chr 7: 20.13 – 20.22 MbChr 12: 119.28 – 119.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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MACC1 is a key regulator of the hepatocyte growth factor (HGF)-HGF receptor (HGFR) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183742Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041886Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: MACC1, MET transcriptional regulator". Retrieved 2018-08-02.
  6. ^ Stein U, Walther W, Arlt F, Schwabe H, Smith J, Fichtner I, et al. (January 2009). "MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis". Nature Medicine. 15 (1): 59–67. doi:10.1038/nm.1889. PMID 19098908. S2CID 8854895.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.