28S ribosomal protein S5, mitochondrial, otherwise called uS5m, is a protein that in humans is encoded by the MRPS5 gene.[5]

MRPS5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPS5, MRP-S5, S5mt, mitochondrial ribosomal protein S5, 28S ribosomal protein S5, mitochondrial
External IDsOMIM: 611972; MGI: 1924971; HomoloGene: 32726; GeneCards: MRPS5; OMA:MRPS5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_031902
NM_001321995
NM_001321996
NM_001321997

NM_029963

RefSeq (protein)

NP_001308924
NP_001308925
NP_001308926
NP_114108

NP_084239

Location (UCSC)Chr 2: 95.09 – 95.12 MbChr 2: 127.43 – 127.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S5P family. Pseudogenes corresponding to this gene are found on chromosomes 4q, 5q, and 18q.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000289685Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027374Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: MRPS5 mitochondrial ribosomal protein S5".

Further reading

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  • Overview of all the structural information available in the PDB for UniProt: P82675 (28S ribosomal protein S5, mitochondrial) at the PDBe-KB.