Mitochondrial ribosomal protein S2 (MRPS2), otherwise known as uS2m, is a protein that in humans is encoded by the MRPS2 gene. [5]

MRPS2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPS2, MRP-S2, S2mt, CGI-91, mitochondrial ribosomal protein S2, COXPD36
External IDsOMIM: 611971; MGI: 2153089; HomoloGene: 99837; GeneCards: MRPS2; OMA:MRPS2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016034
NM_001371401

NM_001166031
NM_080452

RefSeq (protein)

NP_057118
NP_001358330

NP_001159503
NP_536700

Location (UCSC)Chr 9: 135.5 – 135.51 MbChr 2: 28.36 – 28.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S2 family. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012].

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000122140Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035772Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Mitochondrial ribosomal protein S2". Retrieved 2018-02-11.

Further reading

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  • Overview of all the structural information available in the PDB for UniProt: Q9Y399 (Human 28S ribosomal protein S2, mitochondrial (MRPS2)) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.