Myeloid cell Nuclear Differentiation Antigen is a protein that in humans is encoded as MNDA gene.[3][4][5]

MNDA
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesMNDA, PYHIN3, myeloid cell nuclear differentiation antigen
External IDsOMIM: 159553; HomoloGene: 74438; GeneCards: MNDA; OMA:MNDA - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002432

n/a

RefSeq (protein)

NP_002423

n/a

Location (UCSC)Chr 1: 158.83 – 158.85 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Function

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The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5' UTR, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163563Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Briggs JA, Burrus GR, Stickney BD, Briggs RC (May 1992). "Cloning and expression of the human myeloid cell nuclear differentiation antigen: regulation by interferon alpha". Journal of Cellular Biochemistry. 49 (1): 82–92. doi:10.1002/jcb.240490114. PMID 1644857. S2CID 84296063.
  4. ^ Briggs RC, Briggs JA, Ozer J, Sealy L, Dworkin LL, Kingsmore SF, Seldin MF, Kaur GP, Athwal RS, Dessypris EN (April 1994). "The human myeloid cell nuclear differentiation antigen gene is one of at least two related interferon-inducible genes located on chromosome 1q that are expressed specifically in hematopoietic cells". Blood. 83 (8): 2153–62. doi:10.1182/blood.V83.8.2153.2153. PMID 7512843.
  5. ^ a b "Entrez Gene: MNDA myeloid cell nuclear differentiation antigen".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.