MESP1

Mesoderm posterior 1 homolog (mouse) is a protein that in humans is encoded by the MESP1 gene. MESP1 is a transcription factor that regulates cardiovascular progenitor specification.

MESP1
Identifiers
Aliases	MESP1, bHLHc5, mesoderm posterior bHLH transcription factor 1
External IDs	OMIM: 608689; MGI: 107785; HomoloGene: 32039; GeneCards: MESP1; OMA:MESP1 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q26.1 Start 89,749,875 bp End 89,751,249 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 D2|7 45.16 cM Start 79,441,989 bp End 79,443,536 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon oocyte testicle nasal epithelium secondary oocyte prefrontal cortex amygdala cingulate gyrus anterior cingulate cortex muscle of thigh Top expressed in seminiferous tubule spermatocyte spermatid embryo morula epiblast primitive streak right ventricle embryo submandibular gland More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding protein dimerization activity DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process Notch signaling pathway neurogenesis cardiac ventricle formation regulation of transcription, DNA-templated lateral mesoderm development positive regulation of hepatocyte differentiation positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway negative regulation of mesodermal cell fate specification cardiac muscle cell differentiation positive regulation of Notch signaling pathway involved in heart induction cardiac vascular smooth muscle cell differentiation signal transduction involved in regulation of gene expression heart morphogenesis transcription by RNA polymerase II transcription, DNA-templated sinus venosus morphogenesis heart looping positive regulation of transcription, DNA-templated cardioblast migration cardiac cell fate determination multicellular organism development gastrulation embryonic heart tube morphogenesis growth involved in heart morphogenesis positive regulation of striated muscle cell differentiation cardioblast migration to the midline involved in heart field formation endothelial cell differentiation sinoatrial node cell differentiation negative regulation of endodermal cell fate specification secondary heart field specification cardiac atrium formation negative regulation of transcription, DNA-templated cardioblast anterior-lateral migration mesodermal cell migration positive regulation of Notch signaling pathway positive regulation of transcription by RNA polymerase II mesoderm formation somitogenesis embryonic pattern specification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55897 17292 Ensembl ENSG00000166823 ENSMUSG00000030544 UniProt Q9BRJ9 P97309 RefSeq (mRNA) NM_018670 NM_008588 RefSeq (protein) NP_061140 NP_032614 Location (UCSC) Chr 15: 89.75 – 89.75 Mb Chr 7: 79.44 – 79.44 Mb PubMed search
Wikidata
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Further reading

• David R, Brenner C, Stieber J, Schwarz F, Brunner S, Vollmer M, Mentele E, Müller-Höcker J, Kitajima S, Lickert H, Rupp R, Franz WM (March 2008). "MesP1 drives vertebrate cardiovascular differentiation through Dkk-1-mediated blockade of Wnt-signalling". Nature Cell Biology. 10 (3): 338–45. doi:10.1038/ncb1696. PMID 18297060. S2CID 205286617.
• Islas JF, Liu Y, Weng KC, Robertson MJ, Zhang S, Prejusa A, Harger J, Tikhomirova D, Chopra M, Iyer D, Mercola M, Oshima RG, Willerson JT, Potaman VN, Schwartz RJ (August 2012). "Transcription factors ETS2 and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors". Proceedings of the National Academy of Sciences of the United States of America. 109 (32): 13016–21. Bibcode:2012PNAS..10913016I. doi:10.1073/pnas.1120299109. PMC 3420197. PMID 22826236.
• Saga Y, Hata N, Kobayashi S, Magnuson T, Seldin MF, Taketo MM (September 1996). "MesP1: a novel basic helix-loop-helix protein expressed in the nascent mesodermal cells during mouse gastrulation". Development. 122 (9): 2769–78. doi:10.1242/dev.122.9.2769. PMID 8787751.
• Haraguchi S, Kitajima S, Takagi A, Takeda H, Inoue T, Saga Y (October 2001). "Transcriptional regulation of Mesp1 and Mesp2 genes: differential usage of enhancers during development". Mechanisms of Development. 108 (1–2): 59–69. doi:10.1016/S0925-4773(01)00478-6. PMID 11578861.