The MENTAL or MLN64 NH2-terminal domain is a membrane-spanning domain that is conserved in two late endosomal proteins in vertebrates, MLN64 and MENTHO.[1] The domain is 170 amino acids long.
| MENTAL domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | MENTAL | ||||||||
| Pfam | PF10457 | ||||||||
| InterPro | IPR019498 | ||||||||
| PROSITE | PS51439 | ||||||||
| |||||||||
Current data indicates that this domain allows for dimerization between MLN64 and MENTHO molecules and with themselves.[2] The domain may also direct cholesterol transport.
References edit
- ^ Alpy F, Wendling C, Rio MC, Tomasetto C (2002). "MENTHO, a MLN64 Homologue Devoid of the START Domain". J. Biol. Chem. 277 (18): 50780–7. doi:10.1074/jbc.M208290200. PMID 12393907.
- ^ Alpy F, Latchumanan VK, Kedinger V, Janoshazi A, Thiele C, Wendling C, Rio MC, Tomasetto C (2005). "Functional characterization of the MENTAL domain". J. Biol. Chem. 280 (18): 17945–52. doi:10.1074/jbc.M500723200. PMID 15718238.