Mediator of RNA polymerase II transcription subunit 8 is an enzyme that in humans is encoded by the MED8 gene.[5][6][7]

MED8
Identifiers
AliasesMED8, ARC32, mediator complex subunit 8
External IDsOMIM: 607956; MGI: 1915269; HomoloGene: 10560; GeneCards: MED8; OMA:MED8 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_201542
NM_001001653
NM_052877

NM_001290688
NM_020000
NM_173719

RefSeq (protein)

NP_001001653
NP_443109
NP_963836

NP_001277617
NP_064384
NP_776067

Location (UCSC)Chr 1: 43.38 – 43.39 MbChr 4: 118.27 – 118.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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This gene encodes a protein that is one of more than 20 subunits of the mediator complex, first identified in S. cerevisiae, that is required for activation of transcription. The product of this gene also interacts with elongins B and C, and CUL2 and RBX1, to reconstitute a ubiquitin ligase. Five alternative transcripts encoding four isoforms have been described.[7]

Interactions

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MED8 has been shown to interact with MED26.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000159479Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006392Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Brower CS, Sato S, Tomomori-Sato C, Kamura T, Pause A, Stearman R, Klausner RD, Malik S, Lane WS, Sorokina I, Roeder RG, Conaway JW, Conaway RC (Aug 2002). "Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase". Proc Natl Acad Sci U S A. 99 (16): 10353–8. Bibcode:2002PNAS...9910353B. doi:10.1073/pnas.162424199. PMC 124918. PMID 12149480.
  6. ^ Jiang YW, Veschambre P, Erdjument-Bromage H, Tempst P, Conaway JW, Conaway RC, Kornberg RD (Aug 1998). "Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways". Proc Natl Acad Sci U S A. 95 (15): 8538–43. Bibcode:1998PNAS...95.8538J. doi:10.1073/pnas.95.15.8538. PMC 21111. PMID 9671713.
  7. ^ a b "Entrez Gene: MED8 mediator of RNA polymerase II transcription, subunit 8 homolog (S. cerevisiae)".
  8. ^ Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, Banks CA, Jin J, Cai Y, Washburn MP, Conaway JW, Conaway RC (Jun 2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Mol. Cell. 14 (5): 685–91. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.

Further reading

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