Mediator of RNA polymerase II transcription subunit 6 is one of the subunits of the Mediator complex. It is an enzyme that in humans is encoded by the MED6 gene.[5][6][7]

MED6
Identifiers
AliasesMED6, ARC33, NY-REN-28, mediator complex subunit 6
External IDsOMIM: 602984; MGI: 1917042; HomoloGene: 3990; GeneCards: MED6; OMA:MED6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005466
NM_001284209
NM_001284210
NM_001284211

NM_027213
NM_001347384
NM_001347385
NM_001347386

RefSeq (protein)

NP_001271138
NP_001271139
NP_001271140
NP_005457

NP_001334313
NP_001334314
NP_001334315

Location (UCSC)Chr 14: 70.58 – 70.6 MbChr 12: 81.62 – 81.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Med6
Identifiers
SymbolMed6
PfamPF04934
InterProIPR007018
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Protein family

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This family of proteins represent the transcriptional mediator protein subunit 6 that is required for activation of many RNA polymerase II promoters and which are conserved from yeast to humans.[5]

Interactions

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MED6 has been shown to interact with:

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000133997Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002679Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Lee YC, Min S, Gim BS, Kim YJ (August 1997). "A transcriptional mediator protein that is required for activation of many RNA polymerase II promoters and is conserved from yeast to humans". Mol. Cell. Biol. 17 (8): 4622–32. doi:10.1128/MCB.17.8.4622. PMC 232315. PMID 9234719.
  6. ^ Jiang YW, Veschambre P, Erdjument-Bromage H, Tempst P, Conaway JW, Conaway RC, Kornberg RD (Aug 1998). "Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways". Proc Natl Acad Sci U S A. 95 (15): 8538–8543. Bibcode:1998PNAS...95.8538J. doi:10.1073/pnas.95.15.8538. PMC 21111. PMID 9671713.
  7. ^ "Entrez Gene: MED6 mediator of RNA polymerase II transcription, subunit 6 homolog (S. cerevisiae)".
  8. ^ Yang F, DeBeaumont R, Zhou S, Näär AM (Feb 2004). "The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2339–44. Bibcode:2004PNAS..101.2339Y. doi:10.1073/pnas.0308676100. PMC 356952. PMID 14983011.
  9. ^ Wang G, Cantin GT, Stevens JL, Berk AJ (Jul 2001). "Characterization of mediator complexes from HeLa cell nuclear extract". Mol. Cell. Biol. 21 (14): 4604–13. doi:10.1128/MCB.21.14.4604-4613.2001. PMC 87123. PMID 11416138.
  10. ^ a b Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG (Mar 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol. Cell. 3 (3): 361–70. doi:10.1016/s1097-2765(00)80463-3. PMID 10198638.
  11. ^ a b Kang YK, Guermah M, Yuan CX, Roeder RG (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 2642–7. Bibcode:2002PNAS...99.2642K. doi:10.1073/pnas.261715899. PMC 122401. PMID 11867769.
  12. ^ Sun X, Zhang Y, Cho H, Rickert P, Lees E, Lane W, Reinberg D (Aug 1998). "NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription". Mol. Cell. 2 (2): 213–22. doi:10.1016/s1097-2765(00)80131-8. PMID 9734358.

Further reading

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This article incorporates text from the public domain Pfam and InterPro: IPR007018