MED24

MED24
Identifiers
Aliases	MED24, ARC100, CRSP100, CRSP4, DRIP100, THRAP4, TRAP100, MED5, mediator complex subunit 24
External IDs	OMIM: 607000 MGI: 1344385 HomoloGene: 40795 GeneCards: MED24
Gene location (Human)
Chr.	Chromosome 17 (human)
End	40,061,215 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	98,620,261 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; anterior pituitary; ; gastrocnemius muscle; ; canal of the cervix; ; upper lobe of left lung; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; left uterine tube; ; skin of abdomen; ; minor salivary glands;
	Top expressed in
	superior frontal gyrus; ; entorhinal cortex; ; yolk sac; ; spermatid; ; spermatocyte; ; lip; ; seminiferous tubule; ; cerebellar cortex; ; morula; ; ganglionic eminence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transcription coregulator activity; thyroid hormone receptor binding; protein binding; nuclear receptor coactivator activity; vitamin D receptor binding; signaling receptor activity;
Cellular component	nucleoplasm; nucleus; mediator complex;
Biological process	androgen receptor signaling pathway; regulation of transcription, DNA-templated; intracellular steroid hormone receptor signaling pathway; transcription, DNA-templated; positive regulation of transcription, DNA-templated; transcription initiation from RNA polymerase II promoter; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	9862
	23989
	ENSG00000008838
	ENSMUSG00000017210
	O75448
	Q99K74
	NM_001079518; NM_001267797; NM_014815; NM_001330211
NM_011869; NM_001361993; NM_001361994; NM_001361995; NM_001378926;
	NM_001378927
	NP_001072986; NP_001254726; NP_001317140; NP_055630
NP_035999; NP_001348922; NP_001348923; NP_001348924; NP_001365855;
	NP_001365856
	Wikidata
View/Edit Human	View/Edit Mouse

Mediator of RNA polymerase II transcription subunit 24 is an enzyme that in humans is encoded by the MED24 gene.^[5]

Function edit

This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for this gene.^[5]

Interactions edit

MED24 has been shown to interact with Estrogen receptor alpha,^[6]^[7] Cyclin-dependent kinase 8,^[7]^[8] Calcitriol receptor^[6]^[8] and BRCA1.^[9]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000008838 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000017210 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: THRAP4 thyroid hormone receptor associated protein 4".
^ ^a ^b Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S (Jun 2003). "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome". Cell. 113 (7): 905–17. doi:10.1016/S0092-8674(03)00436-7. PMID 12837248.
^ ^a ^b Kang YK, Guermah M, Yuan CX, Roeder RG (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proceedings of the National Academy of Sciences of the United States of America. 99 (5): 2642–7. Bibcode:2002PNAS...99.2642K. doi:10.1073/pnas.261715899. PMC 122401. PMID 11867769.
^ ^a ^b Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG (Mar 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Molecular Cell. 3 (3): 361–70. doi:10.1016/S1097-2765(00)80463-3. PMID 10198638.
^ Wada O, Oishi H, Takada I, Yanagisawa J, Yano T, Kato S (Aug 2004). "BRCA1 function mediates a TRAP/DRIP complex through direct interaction with TRAP220". Oncogene. 23 (35): 6000–5. doi:10.1038/sj.onc.1207786. PMID 15208681. S2CID 5766716.

Further reading edit

Gustafsson CM, Samuelsson T (Jul 2001). "Mediator--a universal complex in transcriptional regulation". Molecular Microbiology. 41 (1): 1–8. doi:10.1046/j.1365-2958.2001.02481.x. PMID 11454195. S2CID 30224146.
Malik S, Roeder RG (May 2005). "Dynamic regulation of pol II transcription by the mammalian Mediator complex". Trends in Biochemical Sciences. 30 (5): 256–63. doi:10.1016/j.tibs.2005.03.009. PMID 15896744.
Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (Aug 1995). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
Fondell JD, Ge H, Roeder RG (Aug 1996). "Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex". Proceedings of the National Academy of Sciences of the United States of America. 93 (16): 8329–33. Bibcode:1996PNAS...93.8329F. doi:10.1073/pnas.93.16.8329. PMC 38670. PMID 8710870.
Rachez C, Suldan Z, Ward J, Chang CP, Burakov D, Erdjument-Bromage H, Tempst P, Freedman LP (Jun 1998). "A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system". Genes & Development. 12 (12): 1787–800. doi:10.1101/gad.12.12.1787. PMC 316901. PMID 9637681.
Yuan CX, Ito M, Fondell JD, Fu ZY, Roeder RG (Jul 1998). "The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 7939–44. Bibcode:1998PNAS...95.7939Y. doi:10.1073/pnas.95.14.7939. PMC 20908. PMID 9653119.
Gu W, Malik S, Ito M, Yuan CX, Fondell JD, Zhang X, Martinez E, Qin J, Roeder RG (Jan 1999). "A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation". Molecular Cell. 3 (1): 97–108. doi:10.1016/S1097-2765(00)80178-1. PMID 10024883.
Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG (Mar 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Molecular Cell. 3 (3): 361–70. doi:10.1016/S1097-2765(00)80463-3. PMID 10198638.
Rachez C, Lemon BD, Suldan Z, Bromleigh V, Gamble M, Näär AM, Erdjument-Bromage H, Tempst P, Freedman LP (Apr 1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex". Nature. 398 (6730): 824–8. Bibcode:1999Natur.398..824R. doi:10.1038/19783. PMID 10235266. S2CID 204992765.
Näär AM, Beaurang PA, Zhou S, Abraham S, Solomon W, Tjian R (Apr 1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation". Nature. 398 (6730): 828–32. Bibcode:1999Natur.398..828N. doi:10.1038/19789. PMID 10235267. S2CID 23646963.
Ryu S, Tjian R (Jun 1999). "Purification of transcription cofactor complex CRSP". Proceedings of the National Academy of Sciences of the United States of America. 96 (13): 7137–42. Bibcode:1999PNAS...96.7137R. doi:10.1073/pnas.96.13.7137. PMC 22029. PMID 10377381.
Zhang J, Fondell JD (Jul 1999). "Identification of mouse TRAP100: a transcriptional coregulatory factor for thyroid hormone and vitamin D receptors". Molecular Endocrinology. 13 (7): 1130–40. doi:10.1210/mend.13.7.0295. PMID 10406464.
Taatjes DJ, Näär AM, Andel F, Nogales E, Tjian R (Feb 2002). "Structure, function, and activator-induced conformations of the CRSP coactivator". Science. 295 (5557): 1058–62. Bibcode:2002Sci...295.1058T. doi:10.1126/science.1065249. PMID 11834832. S2CID 23446878.
Surapureddi S, Yu S, Bu H, Hashimoto T, Yeldandi AV, Kashireddy P, Cherkaoui-Malki M, Qi C, Zhu YJ, Rao MS, Reddy JK (Sep 2002). "Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator". Proceedings of the National Academy of Sciences of the United States of America. 99 (18): 11836–41. Bibcode:2002PNAS...9911836S. doi:10.1073/pnas.182426699. PMC 129355. PMID 12189208.
Wang Q, Sharma D, Ren Y, Fondell JD (Nov 2002). "A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression". The Journal of Biological Chemistry. 277 (45): 42852–8. doi:10.1074/jbc.M206061200. PMID 12218053.
Sato S, Tomomori-Sato C, Banks CA, Parmely TJ, Sorokina I, Brower CS, Conaway RC, Conaway JW (Dec 2003). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". The Journal of Biological Chemistry. 278 (50): 49671–4. doi:10.1074/jbc.C300444200. PMID 14576168.
Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW (Feb 2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". The Journal of Biological Chemistry. 279 (7): 5846–51. doi:10.1074/jbc.M312523200. PMID 14638676.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000008838 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000017210 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: THRAP4 thyroid hormone receptor associated protein 4".

[pmid12837248-6] Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S (Jun 2003). "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome". Cell. 113 (7): 905–17. doi:10.1016/S0092-8674(03)00436-7. PMID 12837248.

[pmid11867769-7] Kang YK, Guermah M, Yuan CX, Roeder RG (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proceedings of the National Academy of Sciences of the United States of America. 99 (5): 2642–7. Bibcode:2002PNAS...99.2642K. doi:10.1073/pnas.261715899. PMC 122401. PMID 11867769.

[pmid10198638-8] Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG (Mar 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Molecular Cell. 3 (3): 361–70. doi:10.1016/S1097-2765(00)80463-3. PMID 10198638.

[pmid15208681-9] Wada O, Oishi H, Takada I, Yanagisawa J, Yano T, Kato S (Aug 2004). "BRCA1 function mediates a TRAP/DRIP complex through direct interaction with TRAP220". Oncogene. 23 (35): 6000–5. doi:10.1038/sj.onc.1207786. PMID 15208681. S2CID 5766716.

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