Microtubule-associated protein 4 is a protein that in humans is encoded by the MAP4 gene.[5]

MAP4
Identifiers
AliasesMAP4, microtubule associated protein 4
External IDsOMIM: 157132; MGI: 97178; HomoloGene: 1780; GeneCards: MAP4; OMA:MAP4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001134364
NM_001134365
NM_002375
NM_030884
NM_030885

RefSeq (protein)

NP_001127836
NP_002366
NP_112147

Location (UCSC)Chr 3: 47.85 – 48.09 MbChr 9: 109.93 – 110.08 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed, the full-length nature of three of which are supported.[6] uMAP4, the ubiquitous isoform of MAP4, functions in the architecture and positioning of the mitotic spindle in human cells.[7] oMAP4 is predominantly expressed in brain and muscle and has been shown to organise microtubules into antiparallel bundles.[8] mMAP4 is a muscle-specific isoform.[8][9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000047849Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032479Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chapin SJ, Bulinski JC (Jul 1991). "Non-neuronal 210 x 10(3) Mr microtubule-associated protein (MAP4) contains a domain homologous to the microtubule-binding domains of neuronal MAP2 and tau". J Cell Sci. 98. ( Pt 1): 27–36. doi:10.1242/jcs.98.1.27. PMID 1905296.
  6. ^ "Entrez Gene: MAP4 microtubule-associated protein 4".
  7. ^ Samora CP, Mogessie B, Conway L, Ross JL, Straube A, McAinsh AD (7 August 2011). "MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis". Nature Cell Biology. 13 (9): 1040–1050. doi:10.1038/ncb2297. PMID 21822276. S2CID 8869880.
  8. ^ a b Mogessie B, Roth D, Rahil Z, Straube A (21 April 2015). "A novel isoform of MAP4 organises the paraxial microtubule array required for muscle cell differentiation". eLife. 4: e05697. doi:10.7554/eLife.05697. PMC 4423121. PMID 25898002.
  9. ^ Casey LM, Lyon HD, Olmsted JB (April 2003). "Muscle-specific microtubule-associated protein 4 is expressed early in myogenesis and is not sufficient to induce microtubule reorganization". Cell Motility and the Cytoskeleton. 54 (4): 317–36. doi:10.1002/cm.10105. PMID 12601693.

Further reading

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